Evidence map›Paper›PMID 36308994›Full record

ArticleEpidemics2022

Structural identifiability of compartmental models for infectious disease transmission is influenced by data type.

Emmanuelle A Dankwa, Andrew F Brouwer, Christl A Donnelly

Abstract read
In one paragraph

Article in Epidemics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  5. Article
  6. Article
  7. Accurate Estimation of Individual Transmission Rates Through Contact Analytics Using UWB Based Indoor Location Data.International Conference on Smart Applications, Communications and Networking : SmartNets. International Conference on Smart Applications, Communications and Networking · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emmanuelle A DankwaDepartment of Statistics, University of Oxford, 24-29 St Giles', Oxford, United Kingdom.
Andrew F BrouwerDepartment of Epidemiology, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA.
Christl A DonnellyDepartment of Statistics, University of Oxford, 24-29 St Giles', Oxford, United Kingdom; Department of Infectious Disease Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London, United Kingdom. Electronic address: christl.donnelly@stats.ox.ac.uk.

Funding

Modeling the Effects of the Environment on Enteric Pathogen DynamicsU01GM110712 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EISENBERG, JOSEPH N. S. · 2014 to 2018
$3.0M
Medical Research Council MR/R015600/1NIGMS NIH HHS U01 GM110712
6 · The paper itself

Abstract

If model identifiability is not confirmed, inferences from infectious disease transmission models may not be reliable, so they might result in misleading recommendations. Structural identifiability analysis characterises whether it is possible to obtain unique solutions for all unknown model parameters, given the model structure. In this work, we studied the structural identifiability of some typical deterministic compartmental models for infectious disease transmission, focusing on the influence of the data type considered as model output on the identifiability of unknown model parameters, including initial conditions. We defined 26 model versions, each having a unique combination of underlying compartmental structure and data type(s) considered as model output(s). Four compartmental model structures and three common data types in disease surveillance (incidence, prevalence and detected vector counts) were studied. The structural identifiability of some parameters varied depending on the type of model output. In general, models with multiple data types as outputs had more structurally identifiable parameters, than did models with a single data type as output. This study highlights the importance of a careful consideration of data types as an integral part of the inference process with compartmental infectious disease transmission models.

Indexed as

Epidemiological ModelsModels, BiologicalIncidenceCompartmental modelsData typesInfectious disease transmissionInitial conditionsStructural identifiability

Identifiers

PMID36308994
PMCPMC9772104

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.