ArticlePsychiatry research. Neuroimaging2022
Increased insula response to interoceptive attention following mindfulness training is associated with increased body trusting among patients with depression.
Article in Psychiatry research. Neuroimaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Neural correlates of altered interoception in depressive and anxiety disorders: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Pooled it
- Structural and functional brain alterations in subthreshold depression: A multimodal coordinate-based meta-analysis.Human brain mapping · 2024Pooled it
- Change starts with the body: Interoceptive appreciation mediates the effect of mindfulness training on behavior change - an effect moderated by depression severity.Psychiatry research · 2024Trial
- Selective interoception impairments and treatment effects in borderline personality disorder.Translational psychiatry · 2026Article
- Mindfulness-Based Intervention for Treatment of Anxiety Disorders During the Postpartum Period: A 4-Week Proof-of-Concept Randomized Controlled Trial Protocol.Brain sciences · 2026Article
- Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention.Communications biology · 2025Observational
- Depression May Not Be Related to Impaired Interoceptive Sensibility: The Role of Alexithymia.Behavioral sciences (Basel, Switzerland) · 2025Article
- Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI.Journal of mood and anxiety disorders · 2025Article
- Neural regulation of pain anticipation is associated with mindful behavior change in patients with anxiety or depression: A pilot study.Psychiatry research. Neuroimaging · 2025Article
- Interoceptive Awareness and Female Orgasm Frequency and Satisfaction.Brain sciences · 2024Article
- Unveiling the interoception impairment in various major depressive disorder stages.CNS neuroscience & therapeutics · 2024Article
- The Mediating Role of Interoceptive Sensitivity in the Relationship between Physical Activity and Depression Symptoms in College Students.Behavioral sciences (Basel, Switzerland) · 2024Article
- Integrating choice points into mindfulness training for the dissociative subtype of PTSD: A case report.Psychiatry research case reports · 2024Article
- Interoceptive training impacts the neural circuit of the anterior insula cortex.Translational psychiatry · 2024Article
- The relationship between mindfulness and athletes' mental skills may be explained by emotion regulation and self-regulation.BMC sports science, medicine & rehabilitation · 2024Article
- Oxytocin Modulation in Mindfulness-Based Pain Management for Chronic Pain.Life (Basel, Switzerland) · 2024Article
- Inducing a meditative state by artificial perturbations: A mechanistic understanding of brain dynamics underlying meditation.Network neuroscience (Cambridge, Mass.) · 2024Article
- Beyond Gender: Interoceptive Sensibility as a Key Predictor of Body Image Disturbances.Behavioral sciences (Basel, Switzerland) · 2023Article
- Within-Person Modulation of Neural Networks following Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (MABT): A Pilot Study.Brain sciences · 2023Article
- Body image disturbance, interoceptive sensibility and the body schema across female adulthood: a pre-registered study.Frontiers in psychology · 2023Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Interoceptive dysfunction is often present in anxiety and depression. We investigated the effects of an 8-week intervention, Mindfulness Training for Primary Care (MTPC), on brain mechanisms of interoceptive attention among patients with anxiety and/or depression. We hypothesized that fMRI brain response to interoception in the insula, a region known for interoceptive processing, would increase following the MTPC intervention, and that such increases would be associated with post-intervention changes in self-reported measures of interoceptive awareness. Adults (n = 28) with anxiety and/or depression completed baseline and post-intervention fMRI visits, including a task in which they alternated between focusing on their heartbeat (interoception (INT)) and a control visual attention task (exteroception (EXT)). Following MTPC, we observed increased evoked fMRI response (relative to baseline) in left anterior insula during the INT-EXT task contrast (z > 3.1, p < 0.001 corrected). In patients with moderate-to-severe depression as defined by the Patient Reported Outcomes Measurement Information System (PROMIS), increased post-intervention insula response was associated with increased Body Trusting, a subscale of the Multidimensional Assessment of Interoceptive Awareness (z > 3.1, p = 0.007 corrected). This study demonstrates that patients with mood disorders may respond differentially to mindfulness-based treatment depending on depression severity, and that among those who are more depressed, increased trusting in one's own body sensations and experiencing the body as a safe place to attend to may be necessary components of positive responses to mindfulness-based interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.