SynthesisSports medicine - open2022
Comparative Effectiveness of Multiple Exercise Interventions in the Treatment of Mental Health Disorders: A Systematic Review and Network Meta-Analysis.
Synthesis in Sports medicine - open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 18 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 18 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Comparative effectiveness and dose-response relationships of exercise for depressive symptoms in children and adolescents: a Bayesian network meta-analysis.BMC psychiatry · 2026Pooled it
- Physical activity modalities and dosing for postpartum depression, anxiety and quality of life: a network meta-analysis and dose response of randomized trials.BMC public health · 2026Pooled it
- Association Between Physical Activity, Heart Rate Variability and Major Depressive Disorders: An Umbrella Review.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Effects of physical activity on depressive symptoms in middle-aged and younger-old adults: a systematic review and meta-analysis.Frontiers in psychology · 2026Pooled it
- Comparative effects of exercise modalities on depression, anxiety, and stress in university students: a systematic review and network meta-analysis of randomized controlled trials.Frontiers in public health · 2026Pooled it
- Augmentation of psychotherapy with exercise in adult populations affected by posttraumatic stress disorder: a systematic review of randomized controlled trials.European journal of psychotraumatology · 2025Pooled it
- Effect of exercise interventions on depression, anxiety, and self-esteem in children and adolescents: a systematic review and network meta-analysis.BMC public health · 2025Pooled it
- Pooled it
- Does physical activity-based intervention decrease repetitive negative thinking? A systematic review.PloS one · 2025Pooled it
- Effects of urban green exercise on mental health: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Physical activity interventions for post-stroke cognitive recovery: a systematic review and network meta-analysis of comparative effects.Frontiers in neurology · 2025Pooled it
- EPA guidance on lifestyle interventions for adults with severe mental illness: A meta-review of the evidence.European psychiatry : the journal of the Association of European Psychiatrists · 2024Pooled it
- Can mindfulness-based interventions reduce PTSD symptoms? An umbrella review.Journal of anxiety disorders · 2024Pooled it
- Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials.BMJ (Clinical research ed.) · 2024Pooled it
- Physical exercise and major depressive disorder in adults: systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Depression and lifestyle: Focusing on nutrition, exercise, and their possible relevance to molecular mechanisms.Psychiatry and clinical neurosciences · 2023Pooled it
- Adaptogens on Depression-Related Outcomes: A Systematic Integrative Review and Rationale of Synergism with Physical Activity.International journal of environmental research and public health · 2023Pooled it
- Exercise sustains motor function in Parkinson's disease: Evidence from 109 randomized controlled trials on over 4,600 patients.Frontiers in aging neuroscience · 2023Pooled it
- Effects of Exercise Type and Sertraline on Anxiety and Social Behavior in a Female Rat Model of PTSD.Brain and behavior · 2026Article
- Music therapy for mental health in children and adolescents: a systematic review and meta-analysis of randomized trials.Child and adolescent psychiatry and mental health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe efficacy of exercise interventions in the treatment of mental health disorders is well known, but research is lacking on the most efficient exercise type for specific mental health disorders.
objectiveThe present study aimed to compare and rank the effectiveness of various exercise types in the treatment of mental health disorders.
methodsThe PubMed, Web of Science, PsycINFO, SPORTDiscus, CINAHL databases, and the Cochrane Central Register of Controlled Trials as well as Google Scholar were searched up to December 2021. We performed pairwise and network meta-analyses as well as meta-regression analyses for mental health disorders in general and each type of mental health disorder, with alterations in symptom severity as the primary outcome.
resultsA total of 6456 participants from 117 randomized controlled trials were surveyed. The multimodal exercise (71%) had the highest probability of being the most efficient exercise for relieving depressive symptoms. While resistance exercise (60%) was more likely to be the most effective treatment for anxiety disorder, patients with post-traumatic stress disorder (PTSD) benefited more from mind-body exercise (52%). Furthermore, resistance exercise (31%) and multimodal exercise (37%) had more beneficial effects in the treatment of the positive and negative symptoms of schizophrenia, respectively. The length of intervention and exercise frequency independently moderated the effects of mind-body exercise on depressive (coefficient = 0.14, p = .03) and negative schizophrenia (coefficient = 0.96, p = .04) symptoms.
conclusionMultimodal exercise ranked best for treating depressive and negative schizophrenic symptoms, while resistance exercise seemed to be more beneficial for those with anxiety-related and positive schizophrenic symptoms. Mind-body exercise was recommended as the most promising exercise type in the treatment of PTSD. However, the findings should be treated with caution due to potential risk of bias in at least one dimension of assessment and low-to-moderate certainty of evidence. Trial Registration This systematic review was registered in the PROSPERO international prospective register of systematic reviews (CRD42022310237).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.