Evidence map›Paper›PMID 36308560›Full record

ArticleClinical oral investigations2023

Men with Crohn's disease may have an increased risk for head and neck squamous cell carcinoma - a nationwide register study.

Anni Harjunen, Enna Puolakkainen, Hanna K Laine, Jaana Rautava

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Anni Harjunen *Oral Pathology and Oral Radiology, Faculty of Medicine, University of Turku, Turku, Finland.
Enna Puolakkainen *Oral Pathology and Oral Radiology, Faculty of Medicine, University of Turku, Turku, Finland.
Hanna K LaineOral Pathology and Oral Radiology, Faculty of Medicine, University of Turku, Turku, Finland. hanna.k.laine@helsinki.fi.ORCID http://orcid.org/0000-0001-8156-6820
Jaana RautavaOral Pathology and Oral Radiology, Faculty of Medicine, University of Turku, Turku, Finland.
University of Helsinki · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveOur goal was to study inflammatory bowel disease (IBD) patients' risk of head and neck squamous cell carcinoma (HNSCC), compared to general population. MATERIALS AND

methodsWe performed a retrospective nationwide register-based study of Finnish individuals diagnosed with IBD between the years 1995 and 2015. The standardized incidence ratio (SIR) of HNSCC was calculated by comparing the cohort's complementary age-year-sex-person-year incidence to that of the whole Finnish population.

resultsAbout 70,567 patients were diagnosed with IBD (Crohn's disease or ulcerative colitis). Later, 89 of them were diagnosed with HNSCC with mean time of 6.82 years. The incidence of HNSCC was increased in IBD patients compared to the Finnish population expectation (SIR 1.3, 95% CI 1.065-1.614, P = 0.062). When calculating Crohn's disease and ulcerative colitis separately as well as men and women separately, the incidence was particularly increased for men with Crohn's disease (SIR 1.951, 95% CI 1.216-2.935, P = 0.025).

conclusionAn increased risk for HNSCC was found in men with Crohn's disease compared to the Finnish population expectations. CLINICAL RELEVANCE: This study provides information that would improve follow-up protocols and treatment guidelines of IBD.

Indexed as

Colitis, UlcerativeCrohn DiseaseHead and Neck NeoplasmsInflammatory Bowel DiseasesFemaleHumansMaleRetrospective StudiesSquamous Cell Carcinoma of Head and NeckCrohn’s diseaseHead and neck cancerInflammatory bowel diseaseOral cancerUlcerative colitis

Identifiers

PMID36308560
PMCPMC9889498
OpenAlexW4307583327

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.