Evidence map›Paper›PMID 36308541›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2023

Trends in the early care of infants with myelomeningocele in the United States 2012-2018.

Benjamin J Best, Erwin T Cabacungan, Susan S Cohen, Irene Kim, Eileen C Sherburne, Kathleen J Sawin, Audrey Roach, Andrew B Foy

Abstract read
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In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Drivers of care and outcomes for people facing fetal conditions in the United States: a conceptual framework.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Benjamin J BestDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA. bbest@mcw.edu.
Erwin T CabacunganDivision of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Susan S CohenDivision of Neonatology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Irene KimDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Eileen C SherburneDepartment of Neurosurgery, Children's Wisconsin, Milwaukee, WI, USA.
Kathleen J SawinDepartment of Nursing Research and Evidence-Based Practice, Children's Wisconsin, Milwaukee, WI, USA.
Audrey RoachDepartment of Neurosurgery, Children's Wisconsin, Milwaukee, WI, USA.
Andrew B FoyDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Children's Hospital of Wisconsin · USMedical College of Wisconsin · US

Funding

Research Approaches to Improving the Care and Outcomes of People Living with Spina Bifida in Wisconsin: The NSBPRU01DD001240 · DD · CHILDREN'S HOSPITAL OF WISCONSIN · PI SHERBURNE, EILEEN · 2019 to 2023
$456k
NCBDD CDC HHS U01 DD001240
6 · The paper itself

Abstract

purposeThe early care of children with spina bifida has changed with the increasing availability of fetal surgery and evidence that fetal repair improves the long-term outcomes of children with myelomeningocele. We sought to determine current trends in the prevalence and early care of children with myelomeningocele using a national administrative database.

methodsThis is a retrospective, cross-sectional cohort study of infants with spina bifida admitted within the first 28 days of life using the 2012-2018 Healthcare Cost and Utilization Project National Inpatient Database. Patients with spina bifida were identified by ICD code and stratified into a cohort with a coded neonatal repair of the defect and those without a coded repair. This database had no identifier specific for fetal surgery, but it is likely that a substantial number of infants without a coded repair had fetal surgery.

resultsWe identified 5,090 patients with a coded repair and 5,715 without a coded repair. The overall prevalence of spina bifida was 3.94 per 10,000 live births. The percentage of patients without neonatal repair increased during the study period compared to those with repair (p = 0.0002). The cohort without neonatal repair had a higher risk of death (p < 0.001), prematurity (p < 0.001), and low birth weight (p < 0.001). More shunts were placed in patients who underwent neonatal repair (p < 0.001). Patients without neonatal repair were less likely to have public insurance (p = 0.0052) and more likely to reside in zip codes within the highest income quartile (p = 0.0002).

conclusionsThe prevalence of spina bifida from 2012 to 2018 was 3.94 per 10,000 live births, with an increasing number of patients without neonatal repair of the defect, suggesting increased utilization of fetal surgery. Patients without neonatal repair had a higher risk of death, prematurity, and low birth weight but were more likely to have commercial insurance and reside in high-income zip codes.

Indexed as

MeningomyeloceleSpinal DysraphismChildCross-Sectional StudiesFemaleHumansInfantInfant, NewbornPregnancyPrenatal CareRetrospective StudiesUnited StatesEpidemiologyFetal surgeryMyelomeningoceleSpina bifida

Identifiers

PMID36308541
OpenAlexW4307580787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.