Evidence map›Paper›PMID 36308536›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2023

Role of brain 2-[

Antonio Canosa, Alessio Martino, Umberto Manera, Rosario Vasta, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Francesca Di Pede, Vincenzo Arena, Cristina Moglia and 4 more

Open access · hybridAbstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Support vector machine classification ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
  4. Role of 2-[Journal of neurology · 2025
    Article
  5. Article
  6. Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Antonio Canosa *ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy. antonio.canosa@unito.it.ORCID 0000-0001-5876-4079
Alessio Martino *Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy.
Umberto ManeraALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Rosario VastaALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Maurizio GrassanoALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Francesca PalumboALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Sara CabrasALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Francesca Di PedeALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Vincenzo ArenaPositron Emission Tomography Centre AFFIDEA-IRMET S.p.A., Turin, Italy.
Cristina MogliaALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Alessandro GiulianiEnvironment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
Andrea CalvoALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Adriano Chiò *ALS Centre, "Rita Levi Montalcini" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy.
Marco Pagani *Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy.
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITUniversity of Turin · ITInstitute of Cognitive Sciences and Technologies · ITIstituto Superiore di Sanità · ITKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe identification of prognostic tools in amyotrophic lateral sclerosis (ALS) would improve the design of clinical trials, the management of patients, and life planning. We aimed to evaluate the accuracy of brain 2-[

methodsA prospective cohort study enrolled 418 ALS patients, who underwent brain 2-[

resultsData were discretized in three survival profiles: 0-2 years, 2-5 years, and > 5 years. SVM resulted in an error rate < 20% for two out of three classes separately. As for class one, the discriminant clusters included left caudate body and anterior cingulate cortex. The most discriminant regions were bilateral cerebellar pyramid in class two, and right cerebellar dentate nucleus, and left cerebellar nodule in class three.

conclusionBrain 2-[

Indexed as

Amyotrophic Lateral SclerosisFluorodeoxyglucose F18Artificial IntelligenceBrainGlucoseHumansPositron-Emission TomographyProspective StudiesFluorodeoxyglucose F18Glucose2-[18F]FDG-PETAmyotrophic lateral sclerosisPrediction modelSurvival

Identifiers

PMID36308536
PMCPMC9852209
OpenAlexW4307583805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.