Evidence map›Paper›PMID 36308371›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2022

TNF-α-308A allele Carrier Induced to Development of Chronic Lymphocytic Leukemia in Sudanese Population at Earlier Age.

Ameen Abdulaziz Basabaeen, Enaam Abdelrhman Abdelgader, Ebtihal Ahmed Babekir, Nour Mahmoud Abdelateif, Sadia Osman Abdelrahim, Awadalkareem Yasin Awadalkareem Omer, Osama Ali Altayeb, Eman Abbass Fadul, Ibrahim Khider Ibrahim

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Article in Asian Pacific journal of cancer prevention : APJCP, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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5 · Who and what money

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9 authors.

Ameen Abdulaziz BasabaeenDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.ORCID 0000-0003-0958-5212
Enaam Abdelrhman AbdelgaderDepartment of Pathology, Faculty of Medicine, Al Neelain University, Khartoum, Sudan.
Ebtihal Ahmed BabekirDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.
Nour Mahmoud AbdelateifDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.
Sadia Osman AbdelrahimDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.
Awadalkareem Yasin Awadalkareem OmerDepartment of Microbiology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.
Osama Ali AltayebFlow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan.
Eman Abbass FadulFlow Cytometry Laboratory for Leukemia & Lymphoma Diagnosis, Khartoum, Sudan.
Ibrahim Khider IbrahimDepartment of Hematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan.ORCID 0000-0002-8223-5369

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundseveral studies have been performed to investigate the association of TNF-α-308G>ASNP and CLL susceptibility However, the results are inconsistent. This study aimed to investigate the association between TNF-α-308G>ASNP of the TNF-α gene and CLL risk in the Sudanese population and correlated genotypes with clinicopathological features.

methodsA case-control study was conducted in Khartoum state, during the period from April 2017 to April 2018, involved 110 CLL patients and 50 healthy volunteers. Physical examination, Complete Blood Count, and immunophenotype were performed in all patients to confirm the diagnosis. Clinical staging such as Rai and Binet were studied. CD38 and ZAP70 were performed by Flow Cytometry. Blood samples were collected from all participants; DNA was extracted by using ANALYTIKJENA Blood DNA Extraction Kit and analyzed TNF-α-308G>ASNP by using AS-PCR. The statistical analysis was performed using SPSS.

resultsTNF-α-308G>A genotype frequencies were GG (10.0%), GA (87.3%), and AA (2.7%) among the CLL patients, and GG (14.0%), GA (80.0%), and AA (6.0%) in the control group. The comparison of CLL patients with the control group did not show any statistically significant relationship for the genotypic and allelic frequencies. Furthermore, no association was observed between the TNF-α-308G>ASNP and gender, hematological parameters, clinical stages systems, CD38 expression, and ZAP-70 expression. The presence of theTNF-α-308Aallele was associated with a lower mean age.

conclusionsThese results indicate that TNF-α-308G>A genotypes are not involved in the predisposition to the development of CLL. TNF-α-308A allele carrier induced to development of CLL at an earlier age.

Indexed as

Leukemia, Lymphocytic, Chronic, B-CellTumor Necrosis Factor-alphaAllelesCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideTumor Necrosis Factor-alphaClinicalCLLmarkers(rs1800629)Susceptibility

Identifiers

PMID36308371
PMCPMC9924346

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