ArticleAdvanced healthcare materials2023
Swelling-Dependent Shape-Based Transformation of a Human Mesenchymal Stromal Cells-Laden 4D Bioprinted Construct for Cartilage Tissue Engineering.
Article in Advanced healthcare materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 88 citations in OpenAlex.
- Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Engineering heterogeneous tissues and organs via multi-material bioprinting: Advances, challenges, and opportunities.Acta biomaterialia · 2026Review
- Discrete 2D Material Programming for 3D Shaping and Morphogenesis-Inspired 4D Bioprinting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reprogrammable 4D tissue engineering hydrogel scaffold via reversible ion printing.Bioactive materials · 2026Article
- In Situ Programming of Shape-Morphing Hydrogels via Vat Photopolymerization for 4D Bioprinting.Gels (Basel, Switzerland) · 2026Article
- Unconventional bioprinting modalities for advanced tissue biofabrication.Biomaterials · 2026Review
- Three-tier framework for high-throughput biofabrication: Integrating 3D bioprinting, assistive platforms, and translational opportunities.Bioactive materials · 2026Review
- Alginate-Based Hydrogels: Recent Progress in Preparation, Property Tuning, and Multifunctional Applications.Gels (Basel, Switzerland) · 2026Review
- Rational Design and Functionalization of Melt Electrowritten 4D Scaffolds for Biomedical Applications.Nano-micro letters · 2026Review
- 3D-bioprinting for joint regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Progressing Regenerative Medicine: Integrating Bioprinting Platforms for Stem Cell Applications.Stem cells international · 2026Review
- Cell Contractile Force-Mediated Morphogenetic Tissue Engineering via 4D Printed Degradable Hydrogel Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Intelligent microstructure materials for diagnosis and treatment of osteoarthritis: progress and AI-enpowered future.Bone research · 2025Review
- Facile Single-Nanocomposite 4D Bioprinting of Dynamic Hydrogel Constructs with Thickness-Controlled Gradient.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 4D-printed microdevices for spatiotemporal detection of ctDNA and miRNA in pancreatic cancer: an in-depth review.Medical oncology (Northwood, London, England) · 2025Review
- Construction of organoids using bioprinting technology: a frontier exploration of cartilage repair.Journal of orthopaedic translation · 2025Review
- Transformative bioprinting: 4D printing and its role in the evolution of engineering and personalized medicine.Discover nano · 2025Review
- 4D printing polymeric biomaterials for adaptive tissue regeneration.Bioactive materials · 2025Review
- 4D bioprinted self-folding scaffolds enhance cartilage formation in the engineering of trachea.Advanced materials technologies · 2025Article
- Programmed shape transformations in cell-laden granular composites.Science advances · 2025Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
3D bioprinting is usually implemented on flat surfaces, posing serious limitations in the fabrication of multilayered curved constructs. 4D bioprinting, combining 3D bioprinting with time-dependent stimuli-induced transformation, enables the fabrication of shape-changing constructs. Here, a 4D biofabrication method is reported for cartilage engineering based on the differential swelling of a smart multi-material system made from two hydrogel-based materials: hyaluronan and alginate. Two ink formulations are used: tyramine-functionalized hyaluronan (HAT, high-swelling) and alginate with HAT (AHAT, low-swelling). Both inks have similar elastic, shear-thinning, and printability behavior. The inks are 3D printed into a bilayered scaffold before triggering the shape-change by using liquid immersion as stimulus. In time (4D), the differential swelling between the two zones leads to the scaffold's self-bending. Different designs are made to tune the radius of curvature and shape. A bioprinted formulation of AHAT and human bone marrow cells demonstrates high cell viability. After 28 days in chondrogenic medium, the curvature is clearly present while cartilage-like matrix production is visible on histology. A proof-of-concept of the recently emerged technology of 4D bioprinting with a specific application for the design of curved structures potentially mimicking the curvature and multilayer cellular nature of native cartilage is demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.