Evidence map›Paper›PMID 36308021›Full record

ArticleLeukemia & lymphoma2023

Impact of multi-agent systemic therapy on all-cause and disease-specific survival for people living with HIV who are diagnosed with non-Hodgkin lymphoma: population-based analyses from the state of Georgia.

Joseph Lipscomb, Jeffrey M Switchenko, Christopher R Flowers, Theresa W Gillespie, Pascale M Wortley, A Rana Bayakly, Lyn Almon, Kevin C Ward

Abstract read
In one paragraph

Article in Leukemia & lymphoma, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joseph LipscombDepartment of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Jeffrey M SwitchenkoWinship Cancer Institute, Emory University, Atlanta, GA, USA.
Christopher R FlowersDivision of Cancer Medicine, Department of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX, USA.
Theresa W GillespieWinship Cancer Institute, Emory University, Atlanta, GA, USA.
Pascale M WortleyGeorgia Department of Public Health, Atlanta, GA.
A Rana BayaklyGeorgia Department of Public Health, Atlanta, GA.
Lyn AlmonGeorgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Kevin C WardGeorgia Center for Cancer Statistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
GEORGIA COMPREHENSIVE CANCER CONTROL PROGRAMU58DP003875 · DP · GEORGIA DIVISION OF PUBLIC HEALTH · PI O'CONNOR, JEAN CATHERINE · 2012 to 2014
$15.9M
NCCDPHP CDC HHS U58 DP003875NCI NIH HHS HHSN261201800003CNCI NIH HHS P30 CA138292NIAID NIH HHS P30 AI050409
6 · The paper itself

Abstract

For people living with HIV (PLWH) who are subsequently diagnosed with non-Hodgkin lymphoma (NHL), we investigate the impact of standard-of-care (SoC) cancer treatment on all-cause, NHL-specific, and HIV-specific survival outcomes. The focus is on a registry-derived, population-based sample of HIV + adults diagnosed with NHL within 2004-2012 in the state of Georgia. SoC treatment is defined as receipt of multi-agent systemic therapy (MAST). In multivariable survival analyses, SoC cancer treatment is significantly associated with better all-cause and NHL-specific survival, but not better HIV-specific survival across 2004-2017. Having a CD4 count <200 near the time of cancer diagnosis and Ann Arbor stage III/IV disease are associated with worse all-cause and HIV-specific survival; the effects on NHL survival trend negative but are not significant. Future work should expand the geographic base and cancers examined, deepen the level of clinical detail brought to bear, and incorporate the perspectives and recommendations of patients and providers.

Indexed as

HIV InfectionsLymphoma, AIDS-RelatedLymphoma, Non-HodgkinAdultAntiretroviral Therapy, Highly ActiveGeorgiaHumanscompeting risksHIV/AIDSNon-Hodgson lymphomaoutcomes researchstandard-of-care therapysurvival analysis

Identifiers

PMID36308021
PMCPMC9905298

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.