Evidence map›Paper›PMID 36308009›Full record

ReviewJournal of biophotonics2023

Multimodal Raman spectroscopy and optical coherence tomography for biomedical analysis.

Sean Fitzgerald, Jobaida Akhtar, Erik Schartner, Heike Ebendorff-Heidepriem, Anita Mahadevan-Jansen, Jiawen Li

Abstract readReview
In one paragraph

Review in Journal of biophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Towards Optical Biopsy in Glioma Surgery.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sean FitzgeraldVanderbilt Biophotonics Center, Nashville, Tennessee, USA.ORCID 0000-0002-7442-5453
Jobaida AkhtarSchool of Physical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Erik SchartnerSchool of Physical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Heike Ebendorff-HeidepriemSchool of Physical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-4877-7770
Anita Mahadevan-JansenVanderbilt Biophotonics Center, Nashville, Tennessee, USA.ORCID 0000-0002-0491-3769
Jiawen LiInstitute for Photonics and Advanced Sensing, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0001-8818-6070

Funding

Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis MediaR01EB028615 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A, MAHADEVAN-JANSEN, ANITA · 2019 to 2022
$2.5M
Australian Research Council CE140100003National Health and Medical Research Council APP2001646National Health and Medical Research Council GNT2008462NIBIB NIH HHS R01 EB028615Wellcome Trust 105608
6 · The paper itself

Abstract

Optical techniques hold great potential to detect and monitor disease states as they are a fast, non-invasive toolkit. Raman spectroscopy (RS) in particular is a powerful label-free method capable of quantifying the biomolecular content of tissues. Still, spontaneous Raman scattering lacks information about tissue morphology due to its inability to rapidly assess a large field of view. Optical Coherence Tomography (OCT) is an interferometric optical method capable of fast, depth-resolved imaging of tissue morphology, but lacks detailed molecular contrast. In many cases, pairing label-free techniques into multimodal systems allows for a more diverse field of applications. Integrating RS and OCT into a single instrument allows for both structural imaging and biochemical interrogation of tissues and therefore offers a more comprehensive means for clinical diagnosis. This review summarizes the efforts made to date toward combining spontaneous RS-OCT instrumentation for biomedical analysis, including insights into primary design considerations and data interpretation.

Indexed as

Spectrum Analysis, RamanTomography, Optical CoherenceInterferometrybiomedicallabel-freemultimodaloptical coherence tomographyRaman spectroscopy

Identifiers

PMID36308009
PMCPMC10082563

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.