Evidence map›Paper›PMID 36307906›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2022

Cell-Taxi: Mesenchymal Cells Carry and Transport Clusters of Cancer Cells.

Jana Zarubova, Mohammad Mahdi Hasani-Sadrabadi, Sam C P Norris, Fatemeh Sadat Majedi, Crystal Xiao, Andrea M Kasko, Song Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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  6. Multi-stage mechanisms of tumor metastasis and therapeutic strategies.Signal transduction and targeted therapy · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jana ZarubovaDepartment of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.ORCID 0000-0002-9647-9997
Mohammad Mahdi Hasani-SadrabadiDepartment of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.
Sam C P NorrisDepartment of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.
Fatemeh Sadat MajediDepartment of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.
Crystal XiaoDepartment of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.
Andrea M KaskoDepartment of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.
Song LiDepartment of Bioengineering, University of California, 420 Westwood Plaza, 5121 Engineering V, Los Angeles, CA, 90095-1600, USA.ORCID 0000-0002-4760-8828

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
Platelets-Mediated Delivery of Checkpoint Inhibitors for Post-Surgical Cancer ImmunotherapyR01CA234343 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2023
$2.0M
Therapeutic microneedles for localized treatment of periodontal tissueR56DE029157 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LI, SONG · 2019 to 2019
$286k
Role of spatial heterogeneous matrix stifness in development of craniofacial tissue interfacesF31DE026356 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NORRIS, SAM CARSTEN-PUISIS · 2017 to 2018
$90k
NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA234343NIDCR NIH HHS F31 DE026356NIDCR NIH HHS R56 DE029157
6 · The paper itself

Abstract

Cell clusters that collectively migrate from primary tumors appear to be far more potent in forming distant metastases than single cancer cells. A better understanding of the collective cell migration phenomenon and the involvement of various cell types during this process is needed. Here, an in vitro platform based on inverted-pyramidal microwells to follow and quantify the collective migration of hundreds of tumor cell clusters at once is developed. These results indicate that mesenchymal stromal cells (MSCs) or cancer-associated fibroblasts (CAFs) in the heterotypic tumor cell clusters may facilitate metastatic dissemination by transporting low-motile cancer cells in a Rac-dependent manner and that extracellular vesicles secreted by mesenchymal cells only play a minor role in this process. Furthermore, in vivo studies show that cancer cell spheroids containing MSCs or CAFs have faster spreading rates. These findings highlight the active role of co-traveling stromal cells in the collective migration of tumor cell clusters and may help in developing better-targeted therapies.

Indexed as

Mesenchymal Stem CellsNeoplasmsCell Line, TumorCell MovementHumansStromal Cellscirculating tumor cell clusterscollective cell migrationextracellular vesiclesmicropatterned hydrogelsspheroid migration assay

Identifiers

PMID36307906
PMCPMC9772300

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.