Evidence map›Paper›PMID 36307893›Full record

ArticleEuropean journal of medical research2022

Neuroprotective effects of donepezil against Aβ

Bu-Lang Gao, Ning-Ning Che, Xue Li, Chun-Feng Ren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Bu-Lang GaoDepartment of Medical Research, Shijiazhuang People's Hospital, 9 Fangbei Road, Shijiazhuang, 050011, Hebei Province, China. browngao@163.com.ORCID http://orcid.org/0000-0003-4668-0737
Ning-Ning CheNeurology, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, 450003, China.
Xue LiNeurology, Henan Provincial People's Hospital, School of Clinical Medicine, Henan University, Zhengzhou, 450003, China.
Chun-Feng RenDepartment of Laboratory Test, First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450003, China.
Henan University · CNFirst Affiliated Hospital of Zhengzhou University · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to investigate the neuroprotective effect of donepezil against β-amyloid

methodsPC12 cells were conventionally cultured. Serial concentrations of Aβ

resultsTreatment with Aβ

conclusionDonepezil can antagonize Aβ

Indexed as

Neuroprotective AgentsAnimalsApoptosisDonepezilHumansIndolesMaleimidesPeptide FragmentsProtein Kinase C-alphaRatsbisindolylmaleimide IDonepezilIndolesMaleimidesNeuroprotective AgentsPeptide FragmentsProtein Kinase C-alphaAlzheimer’s diseaseBeta amyloid 25–35DonepezilNeuroprotectionProtein kinase C

Identifiers

PMID36307893
PMCPMC9617393
OpenAlexW4307711458

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.