ArticleJournal of nanobiotechnology2022
GelMA-MXene hydrogel nerve conduits with microgrooves for spinal cord injury repair.
Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 87 citations in OpenAlex.
- Review
- Two-Dimensional MXene-Loaded Butylphthalide Enhances the Treatment of Alzheimer's Disease by Inhibiting Ferroptosis and Oxidative Stress.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Biomimetic interfacial water-regulated hybrid dual-layer hydrogel for wound healing, anti-adhesion and hemostasis post partial hepatectomy.Materials today. Bio · 2026Article
- Immuno-engineered conductive hydrogels: Bridging neural signaling and microenvironmental remodeling for neural repair.Materials today. Bio · 2026Article
- 3D-MSCs apoptotic bodies-integrated conductive hydrogel mitigates spinal cord injury via immunoregulation and alleviating neuronal pyroptosis.Bioactive materials · 2026Article
- 3D-Printed Piezoionic/Bioelectronic Hydrogel for Electro-Metabolic Regulation of Osteogenic Differentiation.Advanced healthcare materials · 2026Article
- Double-Transition-Metal MXenes: Multimetallic 2D Platforms for Next-Generation Biomedicine.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Bilayer nerve guidance conduits for continuous delivery of NGF@ZIF-8 nanoparticles for peripheral nerve injury repair.Journal of nanobiotechnology · 2026Article
- Electrical Microenvironment Reconstruction and the Application of Biomaterials in Spinal Cord Injury.Journal of functional biomaterials · 2026Review
- Photocrosslinkable Dexamethasone-Loaded GelMA Hydrogel for Peripheral Nerve Injury: Mechanical Behaviour and Anti-Adhesion Effect.Polymers · 2026Article
- 3D printed scaffolds regulated by neural-bone metabolic coupling promote bone unit regeneration.Bioactive materials · 2026Article
- Conductive MXene/adECM hydrogel promotes skeletal muscle regeneration and innervation through CaJournal of nanobiotechnology · 2026Article
- Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine.MedComm · 2026Review
- Graphene and TiACS applied bio materials · 2026Article
- Mechanisms and Applications of Conductive Biomaterials in Spinal Cord Injury Repair.Biomaterials research · 2026Review
- Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug-Releasing Capability for the Programmable Repair of Spinal Cord Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Conductive hydrogel combined with electrical stimulation remodels the microenvironment for nerve regeneration to promote spinal cord injury repair.Journal of nanobiotechnology · 2025Article
- Micro/nano motors treating of digestive system diseases.Journal of nanobiotechnology · 2025Review
- Facile Single-Nanocomposite 4D Bioprinting of Dynamic Hydrogel Constructs with Thickness-Controlled Gradient.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Conductive Nanocomposite Hydrogels for Neural Tissue Engineering: A Systematic Scoping Review of Recent Trends.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons and regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity and internal-facing longitudinal grooves and explore its function in SCI repair. It is found that the resultant grooved GelMA-MXene hydrogel could effectively promote the neural stem cells (NSCs) adhesion, directed proliferation and differentiation in vitro. Additionally, when the GelMA-MXene conduit loaded with NSCs (GMN) is implanted into the injured spinal cord site, effective repair capability for the complete transection of SCI was demonstrated. The GMN group shows remarkable nerve recovery and significantly higher BBB scores in comparison to the other groups. Therefore, GMN with the microgroove structure and loaded with NSCs is a promising strategy in treating SCI.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.