Evidence map›Paper›PMID 36307782›Full record

ArticleBMC musculoskeletal disorders2022

Association between statins and progression of osteoarthritis features on magnetic resonance imaging in a predominantly pre-radiographic cohort: the Vancouver Longitudinal Study of Early Knee Osteoarthritis (VALSEKO): a cohort study.

Jagdeep Gill, Eric C Sayre, Ali Guermazi, Savvas Nicolaou, Jolanda Cibere

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jagdeep GillFaculty of Medicine, University of British Columbia, Vancouver, BC, Canada. jsg01@student.ubc.ca.ORCID https://orcid.org/0000-0002-6252-2125
Eric C SayreArthritis Research Canada, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0002-4526-278X
Ali GuermaziDepartment of Radiology, VA Boston Healthcare System, Boston University School of Medicine, Boston, MA, USA.ORCID https://orcid.org/0000-0002-9374-8266
Savvas NicolaouVancouver Coastal Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0002-4203-6605
Jolanda CibereFaculty of Medicine, University of British Columbia, Vancouver, BC, Canada.ORCID https://orcid.org/0000-0003-2366-1226
University of British Columbia · CABoston University · USResearch Canada · CAVancouver Coastal Health · CA

Funding

Arthritis Society INS-12-027Canadian Arthritis Network 01-MNO-09NCIHR #89890, #89997
6 · The paper itself

Abstract

backgroundTo evaluate the effect of statin use on osteoarthritis (OA) incidence/progression using magnetic resonance imaging (MRI) in a population-based cohort with predominantly pre-radiographic knee OA.

methodsA cohort aged 40-79 years with knee pain was recruited using random population sampling and followed for 7 years. Baseline exclusions were inflammatory arthritis, recent knee surgery/injury, and inability to undergo MRI. At baseline, current statin use was ascertained. Baseline and follow-up MRIs were read semi-quantitatively for cartilage damage (grade 0-4, 0/1 collapsed, 6 regions), osteophytes (grade 0-3, 8 regions), bone marrow lesions (BML) (grade 0-3, 6 regions) and effusion (grade 0-3). The primary outcome was cartilage damage incidence/progression, while secondary outcomes were incidence/progression of osteophytes, BML, and effusion, each defined as an increase by ≥1 grade at any region. To ensure population representative samples, sample weights were used. Logistic regression was used to assess the association of statin use at baseline with incidence/progression of MRI outcomes. Analyses were adjusted for sex, age, BMI, and multiple comorbidities requiring statin therapy.

resultsOf 255 participants evaluated at baseline, 122 completed the 7-year follow-up. Statin use was not significantly associated with progression of cartilage damage (OR 0.82; 95% CI 0.17, 4.06), osteophytes (OR 3.48; 95% CI 0.40, 30.31), BML (OR 0.61; 95% CI 0.12, 3.02), or effusion (OR 2.38; 95% CI 0.42, 13.63), after adjusting for confounders.

conclusionIn this population-based cohort of predominantly pre-radiographic knee OA, statins did not affect MRI incidence/progression of cartilage damage, BML, osteophytes or effusion. Therefore, statin use does not appear to affect people with pre-radiographic stages of knee OA.

Indexed as

Cartilage, ArticularHydroxymethylglutaryl-CoA Reductase InhibitorsOsteoarthritis, KneeOsteophyteCohort StudiesDisease ProgressionHumansKnee JointLongitudinal StudiesMagnetic Resonance ImagingHydroxymethylglutaryl-CoA Reductase InhibitorsCartilageDiagnostic imagingMagnetic resonance imagingOsteoarthritisStatins

Identifiers

PMID36307782
PMCPMC9615180
OpenAlexW4307713215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.