Evidence map›Paper›PMID 36307555›Full record

ArticleEuropean radiology2023

Pectus excavatum in motion: dynamic evaluation using real-time MRI.

Daniel Gräfe, Martin Lacher, Illya Martynov, Franz Wolfgang Hirsch, Dirk Voit, Jens Frahm, Harald Busse, Sergio Bruno Sesia, Sebastian Krämer, Peter Zimmermann

Open access · hybridAbstract read
In one paragraph

Article in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Daniel GräfeDepartment of Pediatric Radiology, University Hospital, Leipzig, Germany. daniel.graefe@medizin.uni-leipzig.de.ORCID http://orcid.org/0000-0002-7680-0990
Martin LacherDepartment of Pediatric Surgery, University Hospital, Leipzig, Germany.
Illya MartynovDepartment of Pediatric Surgery, University Hospital, Leipzig, Germany.
Franz Wolfgang HirschDepartment of Pediatric Radiology, University Hospital, Leipzig, Germany.
Dirk VoitBiomedizinische NMR, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany.
Jens FrahmBiomedizinische NMR, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany.
Harald BusseDepartment of Diagnostic and Interventional Radiology, University Hospital, Leipzig, Germany.
Sergio Bruno SesiaDivision of General Thoracic Surgery, Bern University Hospital, Bern, Switzerland.
Sebastian KrämerDivision of General Thoracic Surgery, Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital, Leipzig, Germany.
Peter ZimmermannDepartment of Pediatric Surgery, University Hospital, Leipzig, Germany.
University Hospital Leipzig · DEMax Planck Institute for Biophysical Chemistry · DEUniversity Hospital of Bern · CH

Funding

European Society for Pediatric Radiology Guy Sebag Grant 2019
6 · The paper itself

Abstract

objectivesThe breathing phase for the determination of thoracic indices in patients with pectus excavatum is not standardized. The aim of this study was to identify the best period for reliable assessments of morphologic indices by dynamic observations of the chest wall using real-time MRI.

methodsIn this prospective study, patients with pectus excavatum underwent morphologic evaluation by real-time MRI at 3 T between January 2020 and June 2021. The Haller index (HI), correction index (CI), modified asymmetry index (AI), and modified eccentricity index (EI) were determined during free, quiet, and forced breathing respectively. Breathing-related differences in the thoracic indices were analyzed with the Wilcoxon signed-rank test. Motion of the anterior chest wall was analyzed as well.

resultsA total of 56 patients (11 females and 45 males, median age 15.4 years, interquartile range 14.3-16.9) were included. In quiet expiration, the median HI in the cohort equaled 5.7 (4.5-7.2). The median absolute differences (Δ) in the thoracic indices between peak inspiration and peak expiration were ΔHI = 1.1 (0.7-1.6, p < .001), ΔCI = 4.8% (1.3-7.5%, p < .001), ΔAI = 3.0% (1.0-5.0%, p < .001), and ΔEI = 8.0% (3.0-14.0%, p < .05). The indices varied significantly during different inspiratory phases, but not during expiration (p > .05 each). Furthermore, the dynamic evaluation revealed three distinctive movement patterns of the funnel chest.

conclusionsReal-time MRI reveals patterns of chest wall motion and indicate that thoracic indices of pectus excavatum should be assessed in the end-expiratory phase of quiet expiration. KEY POINTS: • The thoracic indices in patients with pectus excavatum depend on the breathing phase. • Quiet expiration represents the best breathing phase for determining thoracic indices. • Real-time MRI can identify different chest wall motion patterns in pectus excavatum.

Indexed as

Funnel ChestAdolescentFemaleHumansMagnetic Resonance ImagingMaleMotionProspective StudiesThoraxFunnel chestMagnetic resonance imagingThoracic wall

Identifiers

PMID36307555
PMCPMC9935721
OpenAlexW4307581320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.