ArticleNature communications2022
Synthesis of N-acyl sulfenamides via copper catalysis and their use as S-sulfenylating reagents of thiols.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 67 citations in OpenAlex.
- Accelerating Reaction Discovery through AI-HTE Integration: Nitrene-Mediated C-O Coupling as a Validated Case Study.JACS Au · 2026Article
- From alkynes to spiroindole δ-lactamsChemical science · 2026Article
- Synthesis and characterization of electroactive chitosan/gelatin/PEDOT:PSS hydrogels with mixed ionic-electronic conductivity for potential wound healing applications.RSC advances · 2026Article
- Nitrene-mediated aminative N-N-N coupling: facile access to triazene 1-oxides.Chemical science · 2025Article
- Catalytic Amino Group Transfer Reactions Mediated by Photoinduced Nitrene Formation from Rhodium-Hydroxamates.Angewandte Chemie (International ed. in English) · 2025Article
- Nitrene-mediated glycosylation with thioglycoside donors under metal catalysis.Science advances · 2025Article
- Generation of perthiyl radicals for the synthesis of unsymmetric disulfides.Nature communications · 2025Article
- Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations.Beilstein journal of organic chemistry · 2025Review
- Recent advances in synthetic approaches for bioactive cinnamic acid derivatives.Beilstein journal of organic chemistry · 2025Review
- Cu Anchored Carbon Nitride (Cu/CN) Catalyzes Selective Oxidation of Thiol by Controlling Reactive Oxygen Species Generation.ACS nano · 2024Article
- Synthesis of N-Acylsulfenamides from (Hetero)Aryl Iodides and Boronic Acids by One-Pot Sulfur-Arylation and Dealkylation.Angewandte Chemie (International ed. in English) · 2024Article
- Synthesis ofSynthesis · 2023Article
- Synthesis and Application Dichalcogenides as Radical Reagents with Photochemical Technology.Molecules (Basel, Switzerland) · 2023Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sulfur-heteroatom bonds such as S-S and S-N are found in a variety of natural products and often play important roles in biological processes. Despite their widespread applications, the synthesis of sulfenamides, which feature S-N bonds that may be cleaved under mild conditions, remains underdeveloped. Here, we report a method for synthesis of N-acyl sulfenamides via copper-catalyzed nitrene-mediated S-amidation reaction of thiols with dioxazolones. This method is efficient, convenient, and broadly applicable. Moreover, the resulting N-acetyl sulfenamides are highly effective S-sulfenylation reagents for the synthesis of unsymmetrical disulfides under mild conditions. The S-sulfenylation protocol enables facile access to sterically demanding disulfides that are difficult to synthesize by other means.
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