Evidence map›Paper›PMID 36307224›Full record

ArticleNeurology2023

Association of Perfusion Lesion Variables With Functional Outcome in Patients With Mild Stroke and Large Vessel Occlusion Managed Medically.

Peng Wang, Wenhuo Chen, Chushuang Chen, Andrew Bivard, Geng Yu, Mark W Parsons, Longting Lin, INSPIRE

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Impact of arterial occlusion location on early neurological deterioration in patients with minor stroke treated with intravenous thrombolysis. The MINORCAT-END study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  3. Article
  4. Review
  5. Efficacy of intravenous thrombolysis in patients with mild acute ischemic stroke and large vessel occlusion with different hypoperfusion volumes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peng WangFrom the Department of Neurology (P.W., G.Y.), Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College); Zhangzhou Affiliated Hospital of Fujian Medical University (W.C.), China; Faculty of Health (C.C., M.W.P., L.L.), University of Newcastle; Melbourne Brain Centre (A.B.), University of Melbourne; and South Western Sydney Clinical School (M.W.P., L.L.), University of New South Wales, Australia.
Wenhuo ChenFrom the Department of Neurology (P.W., G.Y.), Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College); Zhangzhou Affiliated Hospital of Fujian Medical University (W.C.), China; Faculty of Health (C.C., M.W.P., L.L.), University of Newcastle; Melbourne Brain Centre (A.B.), University of Melbourne; and South Western Sydney Clinical School (M.W.P., L.L.), University of New South Wales, Australia.
Chushuang ChenFrom the Department of Neurology (P.W., G.Y.), Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College); Zhangzhou Affiliated Hospital of Fujian Medical University (W.C.), China; Faculty of Health (C.C., M.W.P., L.L.), University of Newcastle; Melbourne Brain Centre (A.B.), University of Melbourne; and South Western Sydney Clinical School (M.W.P., L.L.), University of New South Wales, Australia.ORCID 0000-0001-6014-846X
Andrew BivardFrom the Department of Neurology (P.W., G.Y.), Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College); Zhangzhou Affiliated Hospital of Fujian Medical University (W.C.), China; Faculty of Health (C.C., M.W.P., L.L.), University of Newcastle; Melbourne Brain Centre (A.B.), University of Melbourne; and South Western Sydney Clinical School (M.W.P., L.L.), University of New South Wales, Australia.ORCID 0000-0001-7762-5832
Geng YuFrom the Department of Neurology (P.W., G.Y.), Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College); Zhangzhou Affiliated Hospital of Fujian Medical University (W.C.), China; Faculty of Health (C.C., M.W.P., L.L.), University of Newcastle; Melbourne Brain Centre (A.B.), University of Melbourne; and South Western Sydney Clinical School (M.W.P., L.L.), University of New South Wales, Australia.
Mark W ParsonsFrom the Department of Neurology (P.W., G.Y.), Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College); Zhangzhou Affiliated Hospital of Fujian Medical University (W.C.), China; Faculty of Health (C.C., M.W.P., L.L.), University of Newcastle; Melbourne Brain Centre (A.B.), University of Melbourne; and South Western Sydney Clinical School (M.W.P., L.L.), University of New South Wales, Australia.
Longting LinFrom the Department of Neurology (P.W., G.Y.), Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College); Zhangzhou Affiliated Hospital of Fujian Medical University (W.C.), China; Faculty of Health (C.C., M.W.P., L.L.), University of Newcastle; Melbourne Brain Centre (A.B.), University of Melbourne; and South Western Sydney Clinical School (M.W.P., L.L.), University of New South Wales, Australia. longting.lin@newcastle.edu.au.ORCID 0000-0001-7104-9846
INSPIRE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe best management of patients with mild stroke and large vessel occlusion (LVO) remains unclear. This study aimed to identify perfusion imaging predictors of poor functional outcome in such patients.

methodsThis cohort study retrospectively selected patients enrolled in the International Stroke Perfusion Imaging Registry between August 2011 and April 2022. The registry enrolled patients with acute ischemic stroke and with baseline CT perfusion scanned within 24 hours of stroke onset. This study identified patients with mild symptoms, defined by an NIH Stroke Scale score of ≤5. Patients with LVO of anterior circulation were selected. This study further selected patients who received medical management and excluded patients who received endovascular treatment. The primary outcome was poor functional outcome defined as a modified Rankin Scale of 3-6 at 3 months. Perfusion lesion was defined by delay time > 3 seconds on CTP. Regression analyses were used to identify clinical and imaging variables that predicted poor functional outcome.

resultsA total of 139 patients with mild stroke were included, of whom 27 (19%) had poor functional outcome. Patients with poor outcome, compared with those with good outcome, had much larger perfusion lesion volume (median 80 mL vs 41 mL, DISCUSSION: A perfusion lesion of ≥65 mL predicted poor functional outcome in mild stroke patients with LVO.

Indexed as

Brain IschemiaIschemic StrokeStrokeCohort StudiesHumansPerfusionRetrospective StudiesThrombectomyTreatment Outcome

Identifiers

PMID36307224
PMCPMC9946183

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.