Evidence map›Paper›PMID 36307212›Full record

ArticleCold Spring Harbor molecular case studies2022

Discovery and functional characterization of the oncogenicity and targetability of a novel

Payal Jain, Sudarshan Iyer, Joshua Straka, Lea F Surrey, Jennifer Pogoriler, Harry Han, Tiffany Smith, Christine Busch, Elizabeth Fox, Marilyn Li and 3 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. A NovelPediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Payal JainCenter for Data Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.ORCID 0000-0002-5914-9083
Sudarshan IyerDepartment of Pediatrics, Oregon Health and Sciences University, Portland, Oregon 97239, USA.
Joshua StrakaCenter for Data Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Lea F SurreyDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Jennifer PogorilerDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Harry HanCenter for Data Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Tiffany SmithCenter for Data Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Christine BuschDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Elizabeth FoxDivision of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Marilyn LiDepartment of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Angela J WaandersDepartment of Pediatrics, Feinberg School of Medicine Northwestern University, Chicago, Illinois 60611, USA.
Adam Resnick *Center for Data Driven Discovery in Biomedicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.
Monika A Davare *Department of Pediatrics, Oregon Health and Sciences University, Portland, Oregon 97239, USA.ORCID 0000-0003-1802-7597
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Resistance Mechanisms in ROS1-Fusion-Driven MalignanciesF30CA247253 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI IYER, SUDARSHAN RAJAN · 2020 to 2024
$242k
NCI NIH HHS F30 CA247253
6 · The paper itself

Abstract

Angiosarcomas are rare, malignant soft tissue tumors in children that arise in a wide range of anatomical locations and have limited targeted therapies available. Here, we report a rare case of a pediatric angiosarcoma (pAS) with Li-Fraumeni syndrome (LFS) expressing a novel

Indexed as

HemangiosarcomaProtein-Tyrosine KinasesAnimalsChildGene FusionHumansMiceNIH 3T3 CellsProtein Kinase InhibitorsProto-Oncogene ProteinsReceptor, Notch1NOTCH1 protein, humanProtein Kinase InhibitorsProtein-Tyrosine KinasesProto-Oncogene ProteinsReceptor, Notch1ROS1 protein, humanmetastatic angiosarcoma

Identifiers

PMID36307212
PMCPMC9632357
OpenAlexW4307842782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.