Trial reportArchives of disease in childhood. Fetal and neonatal edition2023
Nasal high-flow therapy to Optimise Stability during Intubation: the NOSI pilot trial.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06898801 (Neonatal INtubation After "Just-in-time" Audiovisual Training), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neonatal INtubation After "Just-in-time" Audiovisual Training: a Randomised Controlled Trial
Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Interventions to improve neonatal and infant intubation success: a meta-analysis.European journal of pediatrics · 2026Pooled it
- Respiratory support during endotracheal intubation to improve intubation success in neonates.The Cochrane database of systematic reviews · 2026Pooled it
- Respiratory Stabilization for Successful Intubation in Neonates: A Randomized Controlled Trial.Indian pediatrics · 2026Trial
- Pragmatic Respiratory Stabilization During Neonatal Intubation-What Does this Trial Add for Indian NICUs?Indian pediatrics · 2026Article
- Success rates and adverse events during neonatal intubation: Lessons learned from an international registry.Seminars in fetal & neonatal medicine · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn adult patients with acute respiratory failure, nasal high-flow (NHF) therapy at the time of intubation can decrease the duration of hypoxia. The objective of this pilot study was to calculate duration of peripheral oxygen saturation below 75% during single and multiple intubation attempts in order to inform development of a larger definitive trial. DESIGN AND
settingThis double-blinded randomised controlled pilot trial was conducted at a single, tertiary neonatal centre from October 2020 to October 2021.
participantsInfants undergoing oral intubation in neonatal intensive care were included. Infants with upper airway anomalies were excluded.
interventionsInfants were randomly assigned (1:1) to have NHF 6 L/min, FiO
main outcome measuresThe primary outcome was duration of hypoxaemia of <75% up to the time of successful intubation,
results43 infants were enrolled (26 <34 weeks and 17 ≥34 weeks) with 50 intubation episodes. In infants <34 weeks' gestation, median duration of SpO
conclusionThis pilot study showed that it is feasible to provide NHF during intubation attempts. No significant differences were noted in duration of oxygen saturation of <75% between groups; however, this trial was not powered to detect a difference. A larger, higher-powered blinded study is warranted.
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