ArticleCurrent biology : CB2022
The contrasting roles of nitric oxide drive microbial community organization as a function of oxygen presence.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 21 citations in OpenAlex.
- Nitric Oxide Tunes Secreted Metabolite Bioactivity.Molecular microbiology · 2026Article
- A fluorous-phase oxygen optical nanosensor for mitigating redox-active microbial metabolite interference.The Analyst · 2026Article
- Article
- Sculpting Microbial Microenvironments: Spatiotemporal Control via Programmable Electrochemical Gradients.Journal of the American Chemical Society · 2026Review
- Environmental complexity shapes maintenance of bacterial diversity through context-dependent interactions among niche axes.The ISME journal · 2026Article
- Nitric oxide tunes secreted metabolite bioactivity.bioRxiv : the preprint server for biology · 2025Article
- Functional and Genomic Evidence of L-Arginine-Dependent Bacterial Nitric Oxide Synthase Activity inBiology · 2025Article
- Adaptive responses of Trichlorobacter lovleyi to nitrite detoxification reveal overlooked contributions of Geobacterales to nitrate ammonification.The ISME journal · 2025Article
- Emergence and disruption of cooperativity in a denitrifying microbial community.The ISME journal · 2025Article
- Deciphering microbial spatial organization: insights from synthetic and engineered communities.ISME communications · 2025Review
- Review
- Widespread detoxifying NO reductases impart a distinct isotopic fingerprint on NProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Predicted metabolic roles and stress responses provide insights into candidate phyla Hydrogenedentota and Sumerlaeota as members of the rare biosphere in biofilms from various environments.Environmental microbiology reports · 2024Article
- Denitrification in low oxic environments increases the accumulation of nitrogen oxide intermediates and modulates the evolutionary potential of microbial populations.Environmental microbiology reports · 2024Article
- Uncultivated DPANN archaea are ubiquitous inhabitants of global oxygen deficient zones with diverse metabolic potential.bioRxiv : the preprint server for biology · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Microbial assemblages are omnipresent in the biosphere, forming communities on the surfaces of roots and rocks and within living tissues. These communities can exhibit strikingly beautiful compositional structures, with certain members reproducibly occupying particular spatiotemporal microniches. Despite this reproducibility, we lack the ability to explain these spatial patterns. We hypothesize that certain spatial patterns in microbial communities may be explained by the exchange of redox-active metabolites whose biological function is sensitive to microenvironmental gradients. To test this, we developed a simple community consisting of synthetic Pseudomonas aeruginosa strains with a partitioned denitrification pathway: a strict consumer and strict producer of nitric oxide (NO), a key pathway intermediate. Because NO can be both toxic or beneficial depending on the amount of oxygen present, this system provided an opportunity to investigate whether dynamic oxygen gradients can tune metabolic cross-feeding and fitness outcomes in a predictable fashion. Using a combination of genetic analysis, controlled growth environments, and imaging, we show that oxygen availability dictates whether NO cross-feeding is deleterious or mutually beneficial and that this organizing principle maps to the microscale. More generally, this work underscores the importance of considering the double-edged and microenvironmentally tuned roles redox-active metabolites can play in shaping microbial communities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.