Evidence map›Paper›PMID 36306782›Full record

ArticleStem cell reports2022

Patient-derived parathyroid organoids as a tracer and drug-screening application model.

Milou E Noltes, Luc H J Sondorp, Laura Kracht, Inês F Antunes, René Wardenaar, Wendy Kelder, Annelies Kemper, Wiktor Szymanski, Wouter T Zandee, Liesbeth Jansen and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Biomimetic Gland Models with Engineered Stratagems.Research (Washington, D.C.) · 2023
    Review
  12. Metabolism of parathyroid organoids.Frontiers in endocrinology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Milou E NoltesDepartment of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Luc H J SondorpDepartment of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Laura KrachtDepartment of Biomedical Sciences of Cells and Systems, Section Molecular Neurobiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Inês F AntunesDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
René WardenaarDepartment of Ageing Biology/ERIBA, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Wendy KelderDepartment of Surgery, Martini Hospital, Groningen, the Netherlands.
Annelies KemperDepartment of Surgery, Treant Hospital, Hoogeveen, the Netherlands.
Wiktor SzymanskiStratingh Institute for Chemistry, University of Groningen, Groningen, Groningen, the Netherlands; Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Wouter T ZandeeDepartment of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Liesbeth JansenDepartment of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Adrienne H BrouwersDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Robert P CoppesDepartment of Biomedical Sciences of Cells and Systems, Section Molecular Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: r.p.coppes@umcg.nl.
Schelto KruijffDepartment of Surgical Oncology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Electronic address: s.kruijff@umcg.nl.
University Medical Center Groningen · NLUniversity of Groningen · NLMartini Ziekenhuis · NLTreant Zorggroep · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parathyroid diseases are characterized by dysregulation of calcium homeostasis and alterations in parathyroid hormone (PTH) excretion. The development of parathyroid-targeted treatment and imaging tracers could benefit from in vitro models. Therefore, we aim to establish a patient-derived parathyroid organoid model representing human parathyroid tissue. Hyperplastic parathyroid tissue was dispersed, and parathyroid organoids (PTOs) were cultured and characterized. PTO-derived cells exhibited self-renewal over several passages, indicative of the presence of putative stem cells. Immunofluorescence and RNA sequencing confirmed that PTOs phenocopy hyperplastic parathyroid tissue. Exposure of PTOs to increasing calcium concentrations and PTH-lowering drugs resulted in significantly reduced PTH excretion. PTOs showed specific binding of the imaging tracers

Indexed as

Hyperparathyroidism, PrimaryOrganoidsCalciumHumansParathyroid GlandsTechnetium Tc 99m SestamibiCalciumTechnetium Tc 99m Sestamibidrug screeningendocrine diseaseshyperparathyroidismparathyroid glandspatient-derived organoid modelSPECT/PET tracerstem cells

Identifiers

PMID36306782
PMCPMC9669499
OpenAlexW4307447010

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.