ArticleCell2022
TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways.
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Article in Cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 300 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
300citing papers in PubMed, 1 pooled it
31.4field-weighted citation impact, top 1% of its field
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Who cites it
300 citing papers in PubMed, 1 synthesis or guideline pooled it, 425 citations in OpenAlex.
- Gain-of-function Modulation of TREM2 and its Impact on Amyloid-β and Tau Pathologies in Alzheimer's Disease: A Systematic Review and Meta-analysis of Animal Studies.Molecular neurobiology · 2026Pooled it
- MD2-IN-1 restores microglial lysosomal function and attenuates amyloid pathology through TREM2-associated signaling in 5×FAD mice.Acta pharmacologica Sinica · 2026Article
- Graphene Quantum Dots in Neurodegeneration: Protein Aggregation and the Microglial State as Therapeutic Targets.Nanomaterials (Basel, Switzerland) · 2026Review
- Review
- Modeling Tau-Mediated Pathology in Monkey Brain Slices.Biology · 2026Article
- TMEM59 regulates microglial Aβ phagocytosis in a TREM2-dependent manner and acts as a potential therapeutic target for Aβ amyloidosis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Integration of TSPO PET and fluid biomarkers to assess neuroinflammation in Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2026Article
- Total saponins fromJournal of ginseng research · 2026Article
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- Innate immune crosstalk in ALS/FTD pathogenesis.Cell insight · 2026Review
- Sex-specific gut mycobiome dysbiosis activates macrophage dectin-1 signaling to drive neurobehavioral deficits in EcoHIV-infected mice.Brain, behavior, and immunity · 2026Article
- Neuroinflammation in Alzheimer's and Parkinson's diseases: pathogenic mechanisms and therapeutic strategies.Translational neurodegeneration · 2026Review
- Microglia in Alzheimer's Disease: From Homeostatic Guardians to Multifaceted Drivers of Neuropathology.Cells · 2026Review
- TREM2 in neurodegenerative diseases and acute neurological injuries: mechanisms to targeted therapies.Cell communication and signaling : CCS · 2026Review
- Reshaping the immune landscape: next-generation microglia-targeted therapies for Alzheimer's disease.Biological research · 2026Review
- FcγR- and CD9-dependent synapse-engulfing microglia in the thalamus drive cognitive impairment following cortical brain damage in mice.Nature communications · 2026Article
- Microglial checkpoint collapse in Alzheimer's disease: a tri-axial framework for biomarker-informed neuroimmune therapy.Journal of neuroinflammation · 2026Review
- Role Shift of Glial Cells from Physiology to Pathology in Alzheimer's Disease: The Regulatory Impact of Exercise.Neuroscience bulletin · 2026Review
- CSF1R-related leukoencephalopathy: experimental models and potential for treatment.Disease models & mechanisms · 2026Review
- TREM2 in neurodegeneration and diseases.Molecular psychiatry · 2026Review
240 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
23 authors at 4 institutions in 3 countries.
Shoutang WangDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Raki SudanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Vincent PengDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yingyue ZhouDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Siling DuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Carla M YuedeDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Tingting LeiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jinchao HouDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zhangying CaiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Khai NguyenDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Pietro L PolianiPathology Unit, Molecular and Translational Medicine Department, University of Brescia, Brescia 25123, Italy.
Wandy L BeattyDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Yun ChenDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
Siyan CaoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kent LinDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cecilia RodriguesMedical Research Council Centre for Medical Mycology, University of Exeter, Exeter, Devon EX4 4QD, UK.
Ali H EllebedyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Susan GilfillanDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gordon D BrownMedical Research Council Centre for Medical Mycology, University of Exeter, Exeter, Devon EX4 4QD, UK.
David M HoltzmanDepartment of Neurology, Knight Alzheimer's Disease Research Center, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
Simone BrioschiDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: mcolonna@wustl.edu.
Washington University in St. Louis · USUniversity of Exeter · GBHope Center for Neurological Disorders · USUniversity of Brescia · IT
Funding
Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MCLINICAL/LABORATORY TRAINING ACADEMIC GASTROENTEROLOGYT32DK007130 · NIDDK · WASHINGTON UNIVERSITY · PI MATTHEW AARON CIORBA · 1986 to 2026
$8.3MWashington University Rheumatic DiseasesResearch Resource-based CenterP30AR073752 · NIAMS · WASHINGTON UNIVERSITY · PI Christine T. Pham · 2018 to 2026
$7.6MTREM2 IN MICROGLIA BIOLOGY AND ALZHEIMER'S DISEASERF1AG051485 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2021
$3.5MTHERAPEUTIC STRATEGIES FOR ALZHEIMER'S DISEASE BASED ON TREM2 BIOLOGYRF1AG059082 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2019 to 2019
$2.6MIMPACT OF NOVEL REGULATORS OF TREM2 EXPRESSION ON ALZHEIMER'S DISEASER21AG059176 · NIA · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2018 to 2019
$419kMedical Research Council MR/N006364/1Medical Research Council MR/N006364/2Medical Research Council MR/V033417/1NIAMS NIH HHS P30 AR073752NIA NIH HHS R21 AG059176NIA NIH HHS RF1 AG051485NIA NIH HHS RF1 AG059082NIDDK NIH HHS P30 DK052574NIDDK NIH HHS T32 DK007130Wellcome Trust 102705/Z/13/Z
Abstract
Genetic studies have highlighted microglia as pivotal in orchestrating Alzheimer's disease (AD). Microglia that adhere to Aβ plaques acquire a transcriptional signature, "disease-associated microglia" (DAM), which largely emanates from the TREM2-DAP12 receptor complex that transmits intracellular signals through the protein tyrosine kinase SYK. The human TREM2
Indexed as
Alzheimer DiseaseMicrogliaAmyloid beta-PeptidesAnimalsBrainDisease Models, AnimalGlycogen Synthase Kinase 3 betaHumansMembrane GlycoproteinsMicePhosphatidylinositol 3-KinasesPlaque, AmyloidReceptors, ImmunologicSyk KinaseAmyloid beta-PeptidesGlycogen Synthase Kinase 3 betaMembrane GlycoproteinsPhosphatidylinositol 3-KinasesReceptors, ImmunologicSyk KinaseSYK protein, humanTREM2 protein, humanTrem2 protein, mouseAlzheimer's diseaseApoEDectin1GSK-3βimmunotherapymetabolismmicrogliasignalingSykTREM2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.