Evidence map›Paper›PMID 36306721›Full record

ReviewJournal of diabetes and its complications2022

The conundrum of diabetic neuropathies-Past, present, and future.

Lynn Ang, Kara Mizokami-Stout, Stephanie A Eid, Melissa Elafros, Brian Callaghan, Eva L Feldman, Rodica Pop-Busui

Open access · greenAbstract readReview
In one paragraph

Review in Journal of diabetes and its complications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Autonomic neuropathy in diabetes.Archives of endocrinology and metabolism · 2025
    Review
  11. Observational
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lynn AngDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America.
Kara Mizokami-StoutDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America; Ann Arbor Veteran Affairs Hospital, Ann Arbor, MI, United States of America.
Stephanie A EidDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America.
Melissa ElafrosDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America.
Brian CallaghanDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America.
Eva L FeldmanDepartment of Neurology, University of Michigan, Ann Arbor, MI, United States of America.
Rodica Pop-BusuiDepartment of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan, Ann Arbor, MI, United States of America. Electronic address: rpbusui@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WILLIAM H HERMAN · 2013 to 2026
$24.3M
Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Joyce Lee · 2010 to 2026
$20.3M
Integrated Systems Biology Approach to Diabetic Microvascular ComplicationsR24DK082841 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABCOUWER, STEVEN F, BROSIUS, FRANK C · 2008 to 2020
$13.1M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
NIDDK Diabetic Foot Consortium Clinical Research UnitU01DK119083 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RODICA BUSUI (POP-BUSUI), Crystal Murray Holmes · 2018 to 2026
$5.5M
Schwann Cell Senescence and the Secretome Provide a Unifying Mechanism for the Onset and Progression of Diabetic NeuropathyR01DK130913 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eva Lucille Feldman, Junguk Hur · 2022 to 2026
$3.3M
The Effect of High Intensity Interval Training and Surgical Weight Loss On Distal Symmetric Polyneuropathy OutcomesR01DK115687 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CALLAGHAN, BRIAN CHRISTOPHER · 2018 to 2022
$3.1M
Targeting Inflammation with Salsalate as a Novel Therapy for Diabetic NeuropathyR01DK107956 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BUSUI (POP-BUSUI), RODICA, FELDMAN, EVA LUCILLE · 2016 to 2020
$3.0M
UroEDIC Bladder: Bladder Dysfunction in Type 1 DiabetesR01DK116723 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2021 to 2024
$2.5M
NCATS NIH HHS UL1 TR002240NIDDK NIH HHS K23 DK131296NIDDK NIH HHS K24 DK002926NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK107956NIDDK NIH HHS R01 DK115687NIDDK NIH HHS R01 DK116723NIDDK NIH HHS R01 DK130913NIDDK NIH HHS R24 DK082841NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK119083NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255NINDS NIH HHS R25 NS089450
6 · The paper itself

Abstract

Diabetic neuropathy (DN) remains arguably the most prevalent chronic complication in people with both type 1 and type 2 diabetes, including in youth, despite changes in the current standards of clinical care. Additionally, emerging evidence demonstrates that neuropathy affects a large proportion of people with undiagnosed diabetes and/or prediabetes, as well as those with obesity. Here we summarize the latest epidemiology of DN, recent findings regarding the pathophysiology of the disease, as well as current outcome measures for screening and diagnosis, in research and clinical settings. The authors discuss novel perspectives on the impact of social determinants of health in DN development and management, and the latest evidence on effective therapies, including pharmacological and nonpharmacological therapies for neuropathic pain. Throughout the publication, we identify knowledge gaps and the need for future funding to address these gaps, as well as needs to advocate for a personalized care approach to reduce the burden of DN and optimize quality of life for all affected individuals.

Indexed as

Diabetes Mellitus, Type 2Diabetic NeuropathiesNeuralgiaAdolescentHumansMass ScreeningQuality of LifeAutonomic neuropathiesDiabetic peripheral neuropathyEpidemiologyMechanismsNovel risk factorsPersonalized care implementation

Identifiers

PMID36306721
PMCPMC10202025
OpenAlexW4303183575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.