Evidence map›Paper›PMID 36306687›Full record

ArticleNeurobiology of aging2023

Cerebral blood flow predicts multiple demand network activity and fluid intelligence across the adult lifespan.

Shuyi Wu, Lorraine K Tyler, Richard N A Henson, James B Rowe, Cam-Can, Kamen A Tsvetanov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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  12. Neural Contributions to Reduced Fluid Intelligence across the Adult Lifespan.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
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  14. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuyi WuCentre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Cambridge, UK; Department of Management, School of Business, Hong Kong Baptist University, Hong Kong, China.
Lorraine K TylerCentre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Cambridge, UK.
Richard N A HensonMedical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, Cambridge, UK.
James B RoweMedical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, Cambridge, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Cam-CanCentre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Cambridge, UK; Medical Research Council Cognition and Brain Sciences Unit, Department of Psychiatry, Cambridge, UK.
Kamen A TsvetanovCentre for Speech, Language and the Brain, Department of Psychology, University of Cambridge, Cambridge, UK; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK. Electronic address: kat35@cam.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/H008217/1Medical Research Council MC_UU_00005/12Medical Research Council MC_UU_00030/8
6 · The paper itself

Abstract

The preservation of cognitive function in old age is a public health priority. Cerebral hypoperfusion is a hallmark of dementia but its impact on maintaining cognitive ability across the lifespan is less clear. We investigated the relationship between baseline cerebral blood flow (CBF) and blood oxygenation level-dependent (BOLD) response during a fluid reasoning task in a population-based adult lifespan cohort. As age differences in CBF could lead to non-neuronal contributions to the BOLD signal, we introduced commonality analysis to neuroimaging to dissociate performance-related CBF effects from the physiological confounding effects of CBF on the BOLD response. Accounting for CBF, we confirmed that performance- and age-related differences in BOLD responses in the multiple-demand network were implicated in fluid reasoning. Age differences in CBF explained not only performance-related BOLD responses but also performance-independent BOLD responses. Our results suggest that CBF is important for maintaining cognitive function, while its non-neuronal contributions to BOLD signals reflect an age-related confound. Maintaining perfusion into old age may serve to support brain function and preserve cognitive performance.

Indexed as

LongevityMagnetic Resonance ImagingBrainBrain MappingCerebrovascular CirculationHumansIntelligenceOxygenOxygenAgeingCerebral blood flowCommonality analysisFunctional magnetic resonance imaging (fMRI)Multiple demand network

Identifiers

PMID36306687
PMCPMC7613814

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.