Observational studySleep medicine2022
Pregnancy outcomes in infertility patients diagnosed with sleep disordered breathing with wireless wearable sensors.
Observational study in Sleep medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Sleep disturbances and assisted reproduction outcomes in women undergoing IVF/ICSI: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Associations between sleep quality and assisted reproductive technology outcomes: a meta-analysis.Archives of gynecology and obstetrics · 2026Pooled it
- Relationship Between Sleep Disturbances and In Vitro Fertilization Outcomes in Infertile Women: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Heterogeneous effects of sleep and psychological health on pregnancy outcomes in donor insemination: a prospective cohort study.Frontiers in public health · 2026Article
- Does Sleep Quality Affect IVF Outcomes?JBRA assisted reproduction · 2025Review
- Polycystic Ovary Syndrome and the Internet of Things: A Scoping Review.Healthcare (Basel, Switzerland) · 2024Article
- Effect of obstructive sleep apnea on in vitro fertilization outcomes in women with polycystic ovary syndrome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Recent Progress in Long-Term Sleep Monitoring Technology.Biosensors · 2023Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
objectiveTo study the feasibility of home-based assessment of sleep disordered breathing (SDB) on early pregnancy success after in vitro fertilization with novel wearable sensors.
designProspective observational study.
settingPatients 18 to 45 years old undergoing autologous IVF at an academic infertility center. PATIENTS: 30 women (24-44 years old)
interventionParticipants provided medical history, completed sleep surveys, and a single night of home sleep monitoring prior to IVF with a novel, FDA-cleared wireless sensor system (ANNE® Sleep, Sibel Health), to collect continuous measurements of heart rate, respiratory rate, pulse oxygenation, respiratory effort/snoring, peripheral arterial tonometry, pulse arrival time, and pulse transit time, an accepted surrogate of continuous blood pressure generated by pulse arrival time and pulse transit time. Sleep nights were reviewed to derive the apnea hypopnea index (AHI), defined as the average number of apnea or hypopnea events per hour. An AHI of greater than or equal to 5 events/hour was considered abnormal.
main outcome measureRate of clinical pregnancy (defined as intrauterine gestational sac with a yolk sac) after IVF. Logistic regression models were used to estimate the unadjusted and adjusted odds ratio.
resultsThe overall rate of sleep disordered breathing of any severity was 57%. Participants with SDB had a mean AHI of 13.4 compared to 2.7 events/hr (p<0.01), were younger, and more likely to have polycystic ovary syndrome. Of the 29 patients undergoing an embryo transfer, clinical pregnancy and livebirth occurred in 35% of women with SDB compared to 58% without SDB (p = 0.22). After adjusting for age, SDB reduced pregnancy rates but was not statistically significant (aOR 0.23, 95% CI: 0.04-1.5, p = 0.12). Though polycystic ovary syndrome was associated with higher rates of SDB it was not independently associated with lower pregnancy rates.
conclusionScreening for sleep disordered breathing using home-based wireless, wearable sensors was well accepted and easily performed by infertile patients in this cohort. Sleep disordered breathing of any severity was associated with an 77% (95% CI: 0.08-1.8) lower likelihood of clinical pregnancy and live birth independent of underlying diagnosis. Future larger studies will be needed to understand the role of sleep disordered breathing and IVF outcomes.
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Registered trials
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