Evidence map›Paper›PMID 36306537›Full record

ArticleParkinsonism & related disorders2022

Motor and psychiatric features in idiopathic blepharospasm: A data-driven cluster analysis.

Giovanni Defazio, Angelo F Gigante, Mark Hallett, Alfredo Berardelli, Joel S Perlmutter, Brian D Berman, Joseph Jankovic, Tobias Bäumer, Cynthia Comella, Tommaso Ercoli and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 5 countries.

Giovanni DefazioDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Angelo F GiganteSection of Neurology, San Paolo Hospital, Bari, Italy. Electronic address: angelo.gigante@yahoo.it.
Mark HallettHuman Motor Control Section, NINDS, NIH, Bethesda, MD, USA.
Alfredo BerardelliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy; IRCCS NEUROMED, Pozzilli, Italy.
Joel S PerlmutterNeurology, Radiology, Neuroscience, Physical Therapy, Occupational Therapy, Washington University in St. Louis, St Louis, MO, USA.
Brian D BermanVirginia Commonwealth University, Richmond, VA, USA.
Joseph JankovicParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA.
Tobias BäumerInstitute of Systems Motor Science, University of Lübeck, Lübeck, Germany.
Cynthia ComellaRush University Medical Center, New Philadelphia, OH, USA.
Tommaso ErcoliDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Gina FerrazzanoDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Susan H FoxToronto Western Hospital, Krembil Brain Institute, University of Toronto, Canada.
Han-Joon KimDepartment of Neurology and Movement Disorder Centre, Seoul National University Hospital, Seoul, South Korea.
Emile Sami MoukheiberDepartment of Neurology, Johns Hopkins University, Baltimore, MD, USA.
Sarah Pirio RichardsonDepartment of Neurology, University of New Mexico, Albuquerque, NM, USA.
Anne WeissbachParkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, TX, USA; Institute of Systems Motor Science and Institute of Neurogenetics, University of Lübeck, Germany.
Hyder A JinnahDepartment of Neurology and Human Genetics, Emory University, Atlanta, GA, USA.
University of Cagliari · ITUniversity of Lübeck · DEBaylor College of Medicine · USEmory University · USIstituto Neurologico Mediterraneo · ITJohns Hopkins University · USNational Institutes of Health · USOspedale San Paolo · ITRush University Medical Center · USSapienza University of Rome · ITSeoul National University Hospital · KRToronto Western Hospital · CAUniversity of New Mexico · USVirginia Commonwealth University · USWashington University in St. Louis · US

Funding

UNM HSC Clinical and Translational Science CenterUL1TR001449 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CAMPEN, MATTHEW J, PANDHI, NANCY · 2015 to 2024
$36.9M
Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
University of New Mexico Clinical and Translational Science CenterKL2TR001448 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CANNON, JUDY LIN · 2015 to 2024
$3.5M
Dystonia CoalitionU54TR001456 · NCATS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2015 to 2016
$2.5M
Deep phenotyping in blepharospasmR01NS119831 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A, YEO, WOON-HONG · 2021 to 2024
$1.5M
Antigen Decoding by T cellsR01GM109899 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUSE, MORGAN A, WEINER, ORION D · 2014 to 2017
$1.3M
NCATS NIH HHS KL2 TR001448NCATS NIH HHS U54 TR001456NCATS NIH HHS UL1 TR001449NIGMS NIH HHS R01 GM109899NINDS NIH HHS R01 NS119831NINDS NIH HHS U54 NS065701NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

introductionIdiopathic blepharospasm is a clinically heterogeneous dystonia also characterized by non motor symptoms.

methodsWe used a k-means cluster analysis to assess 188 patients with idiopathic blepharospasm in order to identify relatively homogeneous subpopulations of patients, using a set of motor and psychiatric variables to generate the cluster solution.

resultsBlepharospasm patients reached higher scores on scales assessing depressive- and anxiety-related disorders than healthy/disease controls. Cluster analysis suggested the existence of three groups of patients that differed by type of spasms, overall motor severity, and presence/severity of psychiatric problems. The greater severity of motor symptoms was observed in Group 1, the least severity in Group 3, while the severity of blepharospasm in Group 2 was between that observed in Groups 1 and 3. The three motor subtypes also differed by psychiatric features: the lowest severity of psychiatric symptoms was observed in the group with least severe motor symptoms (group 3), while the highest psychiatric severity scores were observed in group 2 that carried intermediate motor severity rather than in the group with more severe motor symptoms (group 1). The three groups did not differ by disease duration, age of onset, sex or other clinical features.

conclusionsThe present study suggests that blepharospasm patients may be classified in different subtypes according to the type of spasms, overall motor severity and presence/severity of depressive symptoms and anxiety.

Indexed as

BlepharospasmDystonic DisordersAnxietyCluster AnalysisHumansSpasmAnxietyBlepharospasmCluster analysisDepression

Identifiers

PMID36306537
PMCPMC11187571
OpenAlexW4304890507

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.