Evidence map›Paper›PMID 36306506›Full record

ArticleJournal of speech, language, and hearing research : JSLHR2022

Mediators, Moderators, and Covariates: Matching Analysis Approach for Improved Precision in Cognitive-Communication Rehabilitation Research.

Emily L Morrow, Melissa C Duff, Lindsay S Mayberry

Open access · greenAbstract read
In one paragraph

Article in Journal of speech, language, and hearing research : JSLHR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

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  8. Story Generation and Narrative Retells in Children Who Are Hard of Hearing and Hearing Children.Journal of speech, language, and hearing research : JSLHR · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emily L MorrowDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-4629-2283
Melissa C DuffDepartment of Hearing and Speech Sciences, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-1759-3634
Lindsay S MayberryDepartment of Medicine, Division of General Internal Medicine & Public Health, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-0654-4151
Google (United States) · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lea K Davis · 2020 to 2026
$10.3M
Learning Health System training program: PROgRESS--Patient/ pRactice Outcomes and Research in Effectiveness and Systems ScienceT32HS026122 · AHRQ · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GRIJALVA, CARLOS G, ROUMIE, CHRISTIANNE L. · 2018 to 2024
$3.5M
Relational Memory as a Model of Behavioral (Dys)Function in Adults with Traumatic Brain InjuryR01NS110661 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COHEN, NEAL J., DUFF, MELISSA C · 2020 to 2024
$3.2M
Sleep and Word Learning Over Time in Adults with Moderate-Severe Traumatic Brain InjuryF31DC019555 · NIDCD · VANDERBILT UNIVERSITY · PI MORROW, EMILY · 2021 to 2022
$43k
AHRQ HHS T32 HS026122NCATS NIH HHS UL1 TR002243NICHD NIH HHS P50 HD103537NIDCD NIH HHS F31 DC019555NINDS NIH HHS R01 NS110661
6 · The paper itself

Abstract

purposeThe dual goals of this tutorial are (a) to increase awareness and use of mediation and moderation models in cognitive-communication rehabilitation research by describing options, benefits, and attainable analytic approaches for researchers with limited resources and sample sizes and (b) to describe how these findings may be interpreted for clinicians consuming research to inform clinical care.

methodWe highlight key insights from the social sciences literature pointing to the risks of common approaches to linear modeling, which may slow progress in clinical-translational research and reduce the clinical utility of our work. We discuss the potential of mediation and moderation analyses to reduce the research-to-practice gap and describe how researchers may begin to implement these models, even in smaller sample sizes. We discuss how these preliminary analyses can help focus resources for larger trials to fully encapsulate the heterogeneity of individuals with cognitive-communication disorders.

resultsIn rehabilitation research, we study groups, but we use the findings from those studies to treat individuals. The most functional clinical research is about more than establishing only whether a given effect exists for an "average person" in the group of interest. It is critical to understand the active ingredients and mechanisms of action by which a given treatment works (mediation) and to know which circumstances, contexts, or individual characteristics might make that treatment most beneficial (moderation).

conclusionsIncreased adoption of mediation and moderation approaches, executed in appropriate steps, could accelerate progress in cognitive-communication rehabilitation research and lead to the development of targeted treatments that work for more clients. In a field that has made limited progress in developing successful interventions for the last several decades, it is critical that we harness new approaches to advance clinical-translational research results for complex, heterogeneous groups with cognitive-communication disorders.

Indexed as

CommunicationRehabilitation ResearchCognitionHumans

Identifiers

PMID36306506
PMCPMC9940892
OpenAlexW4307581344

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.