Evidence map›Paper›PMID 36306499›Full record

ArticleJCO clinical cancer informatics2022

Evaluation of the Clinical Utility of the Bone Metastases Ensemble Trees for Survival Decision Support Platform (BMETS-DSP): A Case-Based Pilot Assessment.

Sara R Alcorn, Anna W LaVigne, Christen R Elledge, Jacob Fiksel, Chen Hu, Lawrence Kleinberg, Adam Levin, Thomas Smith, Zhi Cheng, Kibem Kim and 10 more

Abstract read
In one paragraph

Article in JCO clinical cancer informatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The impact of a web-based prognostic calculator on prognostic confidence in outpatient palliative care.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sara R AlcornDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-4620-5047
Anna W LaVigneDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0001-6872-9357
Christen R ElledgeDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Jacob FikselDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD.ORCID 0000-0001-7067-1334
Chen HuDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-4672-1981
Lawrence KleinbergDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-2473-2305
Adam LevinDepartment of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.ORCID 0000-0003-0450-7821
Thomas SmithDepartment of Orthopedic Surgery, Johns Hopkins School of Medicine, Baltimore, MD.ORCID 0000-0003-3040-6434
Zhi ChengDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0002-9437-1413
Kibem KimDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Avani D RaoDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Lindsey SloanDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Brandi PageDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0001-8663-8141
Susan F StinsonDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0003-3331-5896
K Ranh VoongDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Todd R McNuttDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Michael R BowersDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Theodore L DeWeeseDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.
Scott ZegerDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD.ORCID 0000-0001-8907-1603
Jean L WrightDepartment of Radiation Oncology, University of Minnesota Medical School, Minneapolis, MN.ORCID 0000-0001-5775-6544

Funding

Institute for Clinical and Translational ResearchKL2TR001077 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$9.2M
NCATS NIH HHS KL2 TR001077
6 · The paper itself

Abstract

purposeThe Bone Metastases Ensemble Trees for Survival Decision Support Platform (BMETS-DSP) provides patient-specific survival predictions and evidence-based recommendations to guide multidisciplinary management for symptomatic bone metastases. We assessed the clinical utility of the BMETS-DSP through a pilot prepost design in a simulated clinical environment.

methodsTen Radiation Oncology physicians reviewed 55 patient cases at two time points: without and then with the use of BMETS-DSP. Assessment included 12-month survival estimate, confidence in and likelihood of sharing estimates with patients, and recommendations for open surgery, systemic therapy, hospice referral, and radiotherapy (RT) regimen. Paired statistics compared pre- versus post-DSP outcomes. Reported statistical significance is

resultsPre- versus post-DSP, overestimation of true minus estimated survival time was significantly reduced (mean difference -2.1 [standard deviation 4.1]

conclusionThis pilot study demonstrates that BMETS-DSP significantly improved physician survival estimation accuracy, prognostic confidence, likelihood of sharing prognosis, and use of prognosis-appropriate RT regimens in the care of symptomatic bone metastases, supporting future multi-institutional validation of the platform.

Indexed as

Bone NeoplasmsRadiation OncologyHumansPilot ProjectsPrognosis

Identifiers

PMID36306499
PMCPMC9848564

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.