Evidence map›Paper›PMID 36306392›Full record

ArticleClinical pharmacology and therapeutics2023

Evaluation of Potential Racial Disparities in CYP2C19-Guided P2Y

Larisa H Cavallari, Nita A Limdi, Amber L Beitelshees, James C Lee, Julio D Duarte, Francesco Franchi, Sony Tuteja, Jay Giri, Philip E Empey, Rolf P Kreutz and 12 more

Open access · greenAbstract read
In one paragraph

Article in Clinical pharmacology and therapeutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Association ofBalkan journal of medical genetics : BJMG · 2024
    Article
  4. Circulation · 2024
    Review
  5. Journal of the American Heart Association · 2024
    Article
  6. From genes to drugs:Frontiers in pharmacology · 2024
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 2 countries.

Larisa H CavallariDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0002-7184-5292
Nita A LimdiDepartment of Neurology, Program for Translational Pharmacogenomics and Hugh Kaul Personalized Medicine Institute, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Amber L BeitelsheesDepartment of Medicine and Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
James C LeeDepartment of Pharmacy Practice, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0002-3101-7281
Julio D DuarteDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.
Francesco FranchiUniversity of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Sony TutejaUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-7007-3289
Jay GiriUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Philip E EmpeyDepartment of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7474-2339
Rolf P KreutzIndiana University School of Medicine, Indianapolis, Indiana, USA.
Todd C SkaarIndiana University School of Medicine, Indianapolis, Indiana, USA.
John M AllenDepartment of Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Orlando, Florida, USA.
James C CoonsDepartment of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7193-3751
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0002-8218-1620
Caitrin W McDonoughDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.
James M StevensonDepartment of Pharmacy and Therapeutics, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, USA.
Cameron D ThomasDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.ORCID 0000-0001-5040-2313
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine, University of Florida College of Pharmacy, Gainesville, Florida, USA.
George A StoufferDivision of Cardiology and McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, USA.
Dominick J AngiolilloUniversity of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Craig R LeeDivision of Cardiology and McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3595-5301
IGNITE Network
University of Florida · USUniversity of Pittsburgh · USIndiana University School of MedicineUniversity of North Carolina at Chapel Hill · USUniversity of Pennsylvania · USUniversity of Alabama at Birmingham · USUniversity of Illinois Chicago · USUniversity of Maryland, Baltimore · US

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6M
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2005 to 2014
$20.7M
Sparking Advancements in Genomic MedicineU01HG007269 · NHGRI · UNIVERSITY OF FLORIDA · PI CAVALLARI, LARISA HUMMA, JOHNSON, JULIE A. · 2013 to 2024
$17.0M
Pharmacogenomics of Anti-platlet Intervention-2 (PAPI-2) StudyU01HL105198 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SHULDINER, ALAN R. · 2010 to 2014
$13.6M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Tissue Modeling & Drug Development Shared Resources CoreU54CA233444 · NCI · UNIVERSITY OF FLORIDA · PI JI-HYUN LEE · 2018 to 2026
$12.1M
Predictors of hemorrhage among patients on direct acting oral anticoagulantsR01HL092173 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2008 to 2023
$10.4M
UAB Center for Clinical and Translational Science (CCTS) UL1UL1TR000165 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2012 to 2013
$9.6M
African American Cardiovascular pharmacogenetic CONsorTium (ACCOuNT): discovery and translationU54MD010723 · NIMHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MELTZER, DAVID O, PERERA, MINOLI A · 2016 to 2020
$9.5M
NCATS NIH HHS UL1 TR000005NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR000165NCATS NIH HHS UL1 TR001427NCATS NIH HHS UL1 TR002489NCATS NIH HHS UL1 TR003096NCI NIH HHS U54 CA233444NHGRI NIH HHS T32 HG008958NHGRI NIH HHS U01 HG007269NHGRI NIH HHS U01 HG007762NHGRI NIH HHS U01 HG007775NHGRI NIH HHS U01 HG010245NHLBI NIH HHS K01 HL141690NHLBI NIH HHS K24 HL133373NHLBI NIH HHS R01 HL092173NHLBI NIH HHS R01 HL149752NHLBI NIH HHS U01 HL105198NIGMS NIH HHS U01 GM074492NIMHD NIH HHS U54 MD010723
6 · The paper itself

Abstract

Black patients suffer worse outcomes after percutaneous coronary intervention (PCI) than White patients. Inequities in antiplatelet prescribing may contribute to this health disparity. We compared P2Y

Indexed as

Percutaneous Coronary InterventionPlatelet Aggregation InhibitorsClopidogrelCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C19 InhibitorsGenotypeHumansPurinergic P2Y Receptor AntagonistsTicagrelorClopidogrelCYP2C19 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C19 InhibitorsPlatelet Aggregation InhibitorsPurinergic P2Y Receptor AntagonistsTicagrelor

Identifiers

PMID36306392
PMCPMC9957848
OpenAlexW4307583806

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.