Evidence map›Paper›PMID 36306335›Full record

Trial reportCirculation. Arrhythmia and electrophysiology2022

Left Bundle Branch Pacing Versus Biventricular Pacing for Acute Cardiac Resynchronization in Patients With Heart Failure.

Yixiu Liang, Jingfeng Wang, Xue Gong, Hongyang Lu, Ziqing Yu, Lei Zhang, Minghui Li, Lei Pan, Xueying Chen, Jie Cui and 6 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Arrhythmia and electrophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04505384 (Acute Effects of Left Bundle Branch Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04505384 nacompletednot on this map

Acute Effects of Left Bundle Branch Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy

TypeinterventionalSponsorShanghai Zhongshan HospitalRan2020 to 2021Enrolled25ConditionsHeart Failure, Cardiac Pacing, Artificial, Cardiac Resynchronization TherapyArmsleft bundle branch pacing, biventricular pacing
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Conduction system vs. biventricular pacing in heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  2. Conduction system pacing for cardiac resynchronization therapy: a systematic review.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
  3. Pooled it
  4. Outcomes of Left Bundle Branch Area Pacing in Heart Failure Patients: A Systematic Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Pooled it
  5. Trial
  6. Optimal pace timing for left bundle branch area pacing with or without an additional LV lead: results from the CSPOT study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Article
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  9. Feasibility, safety and outcomes of contrast-free cardiac resynchronisation therapy device implantation: a retrospective cohort comparison.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Article
  10. Review
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  12. Molecular Mechanisms of Cardiac Adaptation After Device Deployment.Journal of cardiovascular development and disease · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Yixiu Liang *Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).ORCID 0000-0001-5467-8958
Jingfeng Wang *Department of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Xue Gong *Department of Cardiology, Deltahealth Hospital (X.G.).
Hongyang LuCardiac Rhythm Management, Medtronic Technology Center, Medtronic (Shanghai) Ltd (H.L.).ORCID 0000-0002-4077-6802
Ziqing YuDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Lei ZhangDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Minghui LiDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Lei PanDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Xueying ChenDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Jie CuiDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Weiwei ZhangDepartment of Cardiology, Shanghai Chest Hospital of Shanghai Jiao Tong University, China (W.Z., R.L.).
Ruogu LiDepartment of Cardiology, Shanghai Chest Hospital of Shanghai Jiao Tong University, China (W.Z., R.L.).
Xiaohong ZhouCardiac Rhythm Management, Medtronic plc., Mounds View, MN (X.Z.).
Weijian HuangDepartment of Cardiology, First Affiliated Hospital of Wenzhou Medical University, China (W.H.).ORCID 0000-0003-2958-134X
Yangang SuDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).
Junbo GeDepartment of Cardiology, Zhongshan Hospital of Fudan University, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Center for Interventional Medicine (Y.L., J.W., Z.Y., L.Z., M.L., L.P., X.C., J.C., Y.S., J.G.).ORCID 0000-0002-9360-7332
Fudan University · CNMedtronic (Ireland) · IEShanghai Chest Hospital · CNOhioHealth · USWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft bundle branch pacing (LBBP) has emerged as an alternative to biventricular pacing (BVP) for delivering cardiac resynchronization therapy. We sought to compare the acute improvement of electrical and mechanical synchrony, and hemodynamics between LBBP and BVP in patients with heart failure and left bundle branch block.

methodsLBBP and BVP were performed and compared in a crossover fashion in patients with heart failure and left bundle branch block undergoing cardiac resynchronization therapy implantation. Electrical synchrony was assessed by QRS duration and area, mechanical synchrony by the SD of time to peak velocity of 12 left ventricular segments (Ts-SD) and interventricular mechanical delay, and hemodynamics by the maximum rate of left ventricular pressure rise (dP/dt

resultsTwenty-one patient with heart failure and left bundle branch block (mean age 67±10 years, 48% male, and 90% nonischemic cause) were included. Both LBBP and BVP provided significant improvements in electrical and mechanical synchrony, and hemodynamics compared to the baseline. Compared with BVP, LBBP achieved a larger reduction in QRS duration (-11 ms [95% CI, -17 to -4 ms];

conclusionsLBBP delivers greater acute electrical and mechanical resynchronization and hemodynamic improvement than BVP in predominantly nonischemic heart failure patients with left bundle branch block. REGISTRATION: URL: https://www. CLINICALTRIALS: gov; Unique identifier: NCT04505384.

Indexed as

Cardiac Resynchronization TherapyHeart FailureAgedBundle-Branch BlockBundle of HisCardiac Pacing, ArtificialElectrocardiographyFemaleHeart Conduction SystemHumansMaleMiddle AgedTreatment OutcomeVentricular Function, Leftbiventricular pacingcardiac resynchronization therapyheart failurehemodynamicsleft bundle branch pacing

Identifiers

PMID36306335
PMCPMC9665950
OpenAlexW4307494036

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.