Evidence map›Paper›PMID 36306211›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Smooth muscle cell FTO regulates contractile function.

Melissa A Luse, Nenja Krüger, Miranda E Good, Lauren A Biwer, Vlad Serbulea, Anita Salamon, Rebecca A Deaton, Norbert Leitinger, Axel Gödecke, Brant E Isakson

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Frontiers in genetics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Melissa A LuseRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Nenja KrügerRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0001-7168-3986
Miranda E GoodMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.
Lauren A BiwerMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.
Vlad SerbuleaRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Anita SalamonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Rebecca A DeatonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0001-7569-1924
Norbert LeitingerRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.
Axel GödeckeInstitute of Animal Developmental and Molecular Biology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.ORCID 0000-0001-9927-130X
Brant E IsaksonRobert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia.ORCID 0000-0002-7692-6294
University of Virginia · USHeinrich Heine University Düsseldorf · DETufts Medical Center · US

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E · 2014 to 2023
$24.0M
BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8M
Mechanisms of Heterocellular Signaling at the Myoenothelial JunctionR01HL088554 · NHLBI · UNIVERSITY OF VIRGINIA · PI ISAKSON, BRANT E, WEISS, MITCHELL J · 2008 to 2017
$3.8M
Vascular Pannexin 1 in Ischemic StrokeR00HL143165 · NHLBI · TUFTS MEDICAL CENTER · PI GOOD, MIRANDA E · 2020 to 2022
$747k
Vascular Pannexin 1 in Ischemic StrokeK99HL143165 · NHLBI · UNIVERSITY OF VIRGINIA · PI GOOD, MIRANDA E · 2018 to 2019
$206k
Pannexin 1 Channels in Cerebral Arterial Myogenic RegulationF32HL131399 · NHLBI · UNIVERSITY OF VIRGINIA · PI GOOD, MIRANDA E · 2016 to 2017
$71k
NHLBI NIH HHS F32 HL131399NHLBI NIH HHS K99 HL143165NHLBI NIH HHS P01 HL120840NHLBI NIH HHS R00 HL143165NHLBI NIH HHS R01 HL088554NHLBI NIH HHS T32 HL007284NIAID NIH HHS T32 AI007163
6 · The paper itself

Abstract

The fat mass and obesity gene (FTO) is a

Indexed as

Genome-Wide Association StudySerum Response FactorAlpha-Ketoglutarate-Dependent Dioxygenase FTOAnimalsHumansMiceMuscle ContractionMyocytes, Smooth MuscleObesityAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanFTO protein, mouseSerum Response Factorblood pressurecontractilefat mass obesitysmooth muscle

Identifiers

PMID36306211
PMCPMC9678421
OpenAlexW4307500920

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.