Evidence map›Paper›PMID 36306207›Full record

ArticleEnvironmental health perspectives2022

Cancer Risk following Residential Exposure to Airborne Polychlorinated Biphenyls: A Danish Register-Based Cohort Study.

Laura Deen, Karin Sørig Hougaard, Alice Clark, Harald William Meyer, Marie Frederiksen, Lars Gunnarsen, Helle Vibeke Andersen, Thomas Hougaard, Kajsa Kirstine Ugelvig Petersen, Niels Erik Ebbehøj and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Impact of Pollution on Cancer: A Systematic Review and Meta-Analysis with Focus on Air Pollution.International journal of environmental research and public health · 2026
    Pooled it
  3. Article
  4. Epidermal growth factor receptor in placental health and disease: pathways, dysfunction, and chemical disruption.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Pets, Genuine Tools of Environmental Pollutant Detection.Animals : an open access journal from MDPI · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Laura DeenDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.ORCID 0000-0003-4443-7098
Karin Sørig HougaardDepartment of Public Health, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
Alice ClarkDepartment of Epidemiology, Novo Nordisk, Copenhagen, Denmark.
Harald William MeyerDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Marie FrederiksenNational Research Centre for the Working Environment, Copenhagen, Denmark.
Lars GunnarsenDepartment of the Built Environment, Aalborg University Copenhagen, Copenhagen, Denmark.
Helle Vibeke AndersenDepartment of the Built Environment, Aalborg University Copenhagen, Copenhagen, Denmark.
Thomas HougaardMangor & Nagel A/S, Copenhagen, Denmark.
Kajsa Kirstine Ugelvig PetersenDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Niels Erik EbbehøjDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Jens Peter BondeDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
Sandra Søgaard TøttenborgDepartment of Occupational and Environmental Medicine, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.
University of Copenhagen · DKFrederiksberg Hospital · DKAalborg University · DKNational Research Centre for the Working Environment · DKNovo Nordisk (Denmark) · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolychlorinated biphenyls (PCBs) are biopersistent chemicals classified as human carcinogens. This classification is primarily based on evidence on higher-chlorinated PCBs found in food. The carcinogenic potential of airborne lower-chlorinated PCBs remains largely unexplored.

objectivesWe aimed to investigate cancer risk following residential exposure to airborne PCBs.

methodsCancer risk was examined in the Health Effects of PCBs in Indoor Air (HESPAIR) cohort of 38,613 residents of two partly PCB-contaminated residential areas in Greater Copenhagen, identified by nationwide registries. PCB exposure was based on relocation dates and indoor air PCB measurements in subsets of apartments. Cancer diagnoses were extracted from the Danish Cancer Registry for the follow-up period of 1970-2018. We estimated adjusted hazard ratios with time-varying cumulative exposure and a 10-y lag using Cox regression.

resultsOverall risk of cancer was not associated with DISCUSSION: In this, to our knowledge, first population-based cohort study of residential exposure to airborne PCBs, we found no association between exposure to PCBs in indoor air in private homes and the risk for most of the specific cancers. Higher risk of liver cancer and meningiomas were observed. https://doi.org/10.1289/EHP10605.

Indexed as

Liver NeoplasmsMeningeal NeoplasmsMeningiomaPolychlorinated BiphenylsCarcinogensCohort StudiesDenmarkHumansMaleCarcinogensPolychlorinated Biphenyls

Identifiers

PMID36306207
PMCPMC9616107
OpenAlexW4307710943

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.