Evidence map›Paper›PMID 36306014›Full record

ArticleCellular and molecular life sciences : CMLS2022

Structure and function of the N-terminal extension of the formin INF2.

Leticia Labat-de-Hoz, Laura Comas, Armando Rubio-Ramos, Javier Casares-Arias, Laura Fernández-Martín, David Pantoja-Uceda, M Teresa Martín, Leonor Kremer, M Angeles Jiménez, Isabel Correas and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Leticia Labat-de-HozCentro de Biología Molecular (CBM) Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0003-3775-3965
Laura ComasInstituto de Química Física Rocasolano (IQFR), Consejo Superior de Investigaciones Científicas, 28006, Madrid, Spain.ORCID http://orcid.org/0000-0002-3843-1231
Armando Rubio-RamosCentro de Biología Molecular (CBM) Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-1032-2500
Javier Casares-AriasCentro de Biología Molecular (CBM) Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0003-3147-5730
Laura Fernández-MartínCentro de Biología Molecular (CBM) Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049, Madrid, Spain.
David Pantoja-UcedaInstituto de Química Física Rocasolano (IQFR), Consejo Superior de Investigaciones Científicas, 28006, Madrid, Spain.ORCID http://orcid.org/0000-0003-4390-6972
M Teresa MartínCentro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas, 28049, Madrid, Spain.
Leonor KremerCentro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-2235-2010
M Angeles JiménezInstituto de Química Física Rocasolano (IQFR), Consejo Superior de Investigaciones Científicas, 28006, Madrid, Spain.ORCID http://orcid.org/0000-0001-6835-5850
Isabel CorreasCentro de Biología Molecular (CBM) Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049, Madrid, Spain.ORCID http://orcid.org/0000-0002-2286-186X
Miguel A AlonsoCentro de Biología Molecular (CBM) Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, 28049, Madrid, Spain. maalonso@cbm.csic.es.ORCID http://orcid.org/0000-0002-7001-8826
Consejo Superior de Investigaciones Científicas · ES

Funding

Comunidad de Madrid B2017/BMD-3817Consejo Superior de Investigaciones Científicas 201720E09Ministerio de Ciencia e Innovación PID2019-105404RB-I00Ministerio de Ciencia e Innovación PID2020-112821GB-I00Ministerio de Ciencia e Innovación PID2021-123179NB-I00
6 · The paper itself

Abstract

In INF2-a formin linked to inherited renal and neurological disease in humans-the DID is preceded by a short N-terminal extension of unknown structure and function. INF2 activation is achieved by Ca

Indexed as

ActinsMicrofilament ProteinsActin CytoskeletonForminsHumansProtein BindingActinsForminsINF2 protein, humanMicrofilament ProteinsActinCalciumCalmodulinForminsINF2NMR

Identifiers

PMID36306014
PMCPMC9616786
OpenAlexW4307464934

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.