Evidence map›Paper›PMID 36305990›Full record

ArticleAnnals of surgical oncology2023

Is Routine Omentectomy a Necessary Component of Cytoreductive Surgery and HIPEC?

Sohini Khan, Nguyen-Huong Doan, Mojgan Hosseini, Kaitlyn Kelly, Jula Veerapong, Andrew M Lowy, Joel Baumgartner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sohini KhanDivision of Surgical Oncology, Department of Surgery, University of California San Diego, La Jolla, CA, USA.
Nguyen-Huong DoanDivision of Surgical Oncology, Department of Surgery, University of California San Diego, La Jolla, CA, USA.
Mojgan HosseiniDepartment of Pathology, University of California San Diego, La Jolla, CA, USA.
Kaitlyn KellyDepartment of Surgery, University of Wisconsin, Madison, WI, USA.
Jula VeerapongDivision of Surgical Oncology, Department of Surgery, University of California San Diego, La Jolla, CA, USA.
Andrew M LowyDivision of Surgical Oncology, Department of Surgery, University of California San Diego, La Jolla, CA, USA.
Joel BaumgartnerDivision of Surgical Oncology, Department of Surgery, University of California San Diego, La Jolla, CA, USA. j1baumgartner@health.ucsd.edu.
University of California, San Diego · USUniversity of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastases traditionally includes omentectomy, even in the absence of visible omental metastases. We sought to determine the rate of occult histologic omental metastasis (OHOM), evaluate morbidity with omentectomy, and examine the rate of omental recurrence among patients undergoing CRS-HIPEC.

methodsAll CRS-HIPEC procedures from August 2007 to August 2020 were included in this single-center, retrospective, cohort study. Procedures were divided into those that included greater omentectomy (OM) and those that did not (NOM). The incidence of OHOM was evaluated specifically among the OM group with a grossly normal omentum. Multivariate regression analyses were performed to evaluate return of bowel function, ileus, and morbidity in the OM and NOM groups.

resultsAmong 683 CRS-HIPEC procedures, 578 (84.6%) included omentectomy and 105 (15.4%) did not. The OM group had higher operative time, blood loss, peritoneal cancer index, number of visceral resections, and length of stay. In the OM group, 72 (12.5%) patients had a grossly normal omentum, and 23 (31.9%) of these had OHOM. Risk-adjusted return of bowel function, ileus, and 60-day complications were no different in the OM and NOM groups. Among 43 patients with residual omentum, 24 (55.8%) recurred, including 9 (20.9%) with omental recurrence.

conclusionsHistologically occult metastasis was present in one-third of patients undergoing omentectomy during CRS-HIPEC. Omentectomy did not increase the rate of overall morbidity, and one-fifth of patients with residual omentum later developed omental recurrence. Thus, omentectomy is warranted in the absence of gross metastases during CRS-HIPEC.

Indexed as

Hyperthermia, InducedIleusPeritoneal NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsCohort StudiesCombined Modality TherapyCytoreduction Surgical ProceduresHumansHyperthermic Intraperitoneal ChemotherapyRetrospective StudiesSurvival Rate

Identifiers

PMID36305990
PMCPMC9807473
OpenAlexW4307499112

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.