Evidence map›Paper›PMID 36305963›Full record

Trial reportClinical oral investigations2023

Effects of oral administration of Bifidobacterium animalis subsp. lactis HN019 on the treatment of plaque-induced generalized gingivitis.

Yara Loyanne de Almeida Silva Levi, Marcella Costa Ribeiro, Pedro Henrique Félix Silva, Giselle Aparecida Silva, Sergio Luiz de Souza Salvador, Sérgio Luís Scombatti de Souza, Renato Casarin, Arthur Belem Novaes Júnior, Mario Taba Júnior, Daniela Bazan Palioto and 3 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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  12. A Three-Month Probiotic (theDentistry journal · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yara Loyanne de Almeida Silva LeviDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Marcella Costa RibeiroDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Pedro Henrique Félix SilvaDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Giselle Aparecida SilvaDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Sergio Luiz de Souza SalvadorDepartment of Clinical Analyses, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo - USP, Ribeirao Preto, , São Paulo, Brazil.
Sérgio Luís Scombatti de SouzaDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Renato CasarinDepartment of Prosthodontics and Periodontics, School of Dentistry, Campinas State University - UNICAMP, Piracicaba, São Paulo, Brazil.
Arthur Belem Novaes JúniorDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Mario Taba JúniorDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Daniela Bazan PaliotoDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Heitor Marques HonórioDepartment of Pediatric Dentistry, Orthodontics and Public Health, School of Dentistry of Bauru, University of São Paulo - USP, Bauru, , São Paulo, Brazil.
Michel Reis MessoraDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil.
Flávia Aparecida Chaves FurlanetoDepartment of Oral Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo - USP, Ribeirão Preto, São Paulo, 14020-150, Brazil. flafurlaneto@usp.br.ORCID http://orcid.org/0000-0002-8072-3983
Universidade de Ribeirão Preto · BRUniversidade de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis double-blind, randomized, placebo-controlled clinical trial evaluated the adjuvant effects of Bifidobacterium lactis HN019 on the treatment of plaque-induced generalized gingivitis. MATERIALS AND

methodsSixty patients were submitted to professional supragingival scaling and prophylaxis. They were randomly assigned to test (probiotic lozenges containing B. lactis HN019, n = 30) or control (placebo lozenges, n = 30) groups. Lozenges were consumed twice a day for 8 weeks. Bleeding on probing (BoP), Gingival Index (GI), Plaque Index (PI), probing depth (PD), and clinical attachment level (CAL) were evaluated at baseline and after 2 and 8 weeks. Gingival crevicular fluid (GCF) was collected at baseline and at 8 weeks for analysis of the inflammatory mediators IL-1β, IL-1α, IL-8, MCP-1, and MIP-1β. Data were statistically analyzed (p < 0.05).

resultsAfter 8 weeks, both groups showed reduction in the percentage of PI, with no significant difference between groups (p = 0.7423). The test group presented a lower percentage of BoP and a higher percentage of sites with GI ≤ 1 when compared with the control group at the end of the study (p < 0.0001). At 8 weeks, the test group had a greater number of patients without generalized gingivitis than the control group (20 and 11 patients, respectively; p < 0.05). The test group presented significantly lower levels of IL-1α, IL-1β, and MCP-1 in GCF than the control group at the end of the study (p < 0.05).

conclusionThe adjunct use of B. lactis HN019 promotes additional clinical and immunological benefits in the treatment of generalized gingivitis. CLINICAL RELEVANCE: B. lactis HN019 can be an efficient and side-effect-free adjunct strategy in the treatment of generalized gingivitis.

Indexed as

Bifidobacterium animalisDental PlaqueGingivitisPlaque, AtheroscleroticAdministration, OralDental ScalingGingival Crevicular FluidHumansBifidobacterium lactisGingivitisProbiotics

Identifiers

PMID36305963
PMCPMC9614197
OpenAlexW4307730493

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.