Evidence map›Paper›PMID 36305958›Full record

ArticleArchives of dermatological research2023

The "Understanding Pyoderma Gangrenosum, Review and Assessment of Disease Effects (UPGRADE)" Project: a protocol for the development of the core outcome domain set for trials in pyoderma gangrenosum.

Jonathan Rick, Lisa J Gould, Angelo Valerio Marzano, Amit Garg, Diana Chen, Debbie L Oakes, Joachim Dissemond, Hans Herfarth, Marcia A Friedman, Afsaneh Alavi and 4 more

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In one paragraph

Article in Archives of dermatological research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Approach to the Atypical Wound.American journal of clinical dermatology · 2024
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

Jonathan RickDepartment of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA. jwrick@uams.edu.
Lisa J GouldSouth Shore Health Center for Wound Healing, Weymouth, MA, USA.
Angelo Valerio MarzanoDermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico and Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy.
Amit GargDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, USA.
Diana ChenGenentech Incorporated, South San Francisco, CA, USA.
Debbie L OakesSouth Shore Health Center for Wound Healing, Weymouth, MA, USA.
Joachim DissemondDepartment of Dermatology, University of Essen-Duisburg, Essen, Germany.
Hans HerfarthDepartment of Internal Medicine, Division of Gastroenterology, University of North Carolina, Chapel Hill, NC, USA.
Marcia A FriedmanDepartment of Internal Medicine, Division of Rheumatology, Oregon Health and Science University, Portland, OR, USA.
Afsaneh AlaviDepartment of Dermatology, Mayo Clinic College of Medicine, Rochester, MN, USA.
Toshiyuki YamamotoDepartment of Dermatology, Fukushima Medical University, Fukushima, Japan.
Louise A A GerbensDepartment of Dermatology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Kim S ThomasSchool of Medicine, Centre of Evidence Based Dermatology, University of Nottingham, Nottingham, UK.
Alex G Ortega-LoayzaDepartment of Dermatology, Oregon Health and Science University, Portland, OR, USA.
Oregon Health & Science University · USSouth Shore Hospital · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USFukushima Medical University · JPMayo Clinic · USUniversity of Amsterdam · NLUniversity of Arkansas for Medical Sciences · USUniversity of Duisburg-Essen · DEUniversity of Milan · ITUniversity of North Carolina at Chapel Hill · USUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPyoderma gangrenosum (PG) is a rare neutrophilic dermatosis that affects approximately 0.3-6 out of every 100,000 people worldwide. Clinical trials are scarce but there is growing interest in using newer and more targeted therapeutics to achieve disease remission. However, there are no standardized instruments to measure outcomes in PG and, therefore, future clinical trials are hampered by the absence of established and accurate means of assessment and comparison. Therefore, we aim to produce an internationally accepted core outcome set (COS) that will overcome this obstacle. This protocol outlines our intended approach to achieve the first part of this process, establishing a core outcome domain set.

methodsAn international team of PG stakeholders, consisting of physicians, wound care nurses, patients, scientists and industry representatives, has been assembled for the purpose of building a comprehensive and universally established set of core outcome domains. During the first step, we will generate items of relevance using a nominal process from all stakeholders. Items will be distilled and collapsed into potential domains and subdomains. A systematic review of current methods for reporting PG has already been published and domains identified in this work will be considered in the generation of the core domains set. During the second step, after the potential domains and subdomains are identified, stakeholders will participate in an e-Delphi exercise to rate the importance of (sub)domains. A final consensus meeting will be organized with the goal of establishing a core domain set.

conclusionPyoderma gangrenosum lacks an established COS and previously published clinical trials have used inconsistent measures established from similarly inconsistent domains. As a first step this study seeks to create a core domain set within the COS, to build the foundation for future core outcome work for PG.

Indexed as

Pyoderma GangrenosumConsensusDelphi TechniqueHumansResearch DesignSystematic Reviews as TopicTreatment OutcomeClinical trialsCore outcomesGangrenosumInflammatoryPyoderma

Identifiers

PMID36305958
OpenAlexW4307493700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.