Evidence map›Paper›PMID 36305864›Full record

ArticleFEBS open bio2023

Analysis of tripartite Synaptotagmin-1-SNARE-complexin-1 complexes in solution.

Klaudia Jaczynska, Luis Esquivies, Richard A Pfuetzner, Baris Alten, Kyle D Brewer, Qiangjun Zhou, Ege T Kavalali, Axel T Brunger, Josep Rizo

Abstract read
In one paragraph

Article in FEBS open bio, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Complexin has a dual synaptic function as checkpoint protein in vesicle priming and as a promoter of vesicle fusion.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. The Core Complex of the CaJournal of molecular biology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Klaudia JaczynskaDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-2113-2320
Luis EsquiviesDepartment of Molecular and Cellular Physiology, Stanford University, CA, USA.
Richard A PfuetznerDepartment of Molecular and Cellular Physiology, Stanford University, CA, USA.
Baris AltenDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-1842-7099
Kyle D BrewerDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Qiangjun ZhouVanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Ege T KavalaliDepartment of Pharmacology, Vanderbilt University, Nashville, TN, USA.
Axel T BrungerDepartment of Molecular and Cellular Physiology, Stanford University, CA, USA.ORCID 0000-0001-5121-2036
Josep RizoDepartment of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1773-8311

Funding

Mechanisms of neurotransmitter release and its regulationR35NS097333 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2017 to 2024
$7.0M
STRUCTURE OF PROTEINS INVOLVED IN SYNAPTIC EXOCYTOSISR01MH063105 · NIMH · STANFORD UNIVERSITY · PI BRUNGER, AXEL T · 2000 to 2025
$4.7M
Molecular Mechanism and Regulation of Asynchronous ReleaseR00MH113764 · NIMH · VANDERBILT UNIVERSITY · PI ZHOU, QIANGJUN · 2020 to 2022
$719k
Acquisition of upgrades for 800 MHz NMR consoleS10OD018027 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI RIZOREY, JOSE · 2014 to 2014
$376k
Molecular Mechanism and Regulation of Asynchronous ReleaseK99MH113764 · NIMH · STANFORD UNIVERSITY · PI ZHOU, QIANGJUN · 2017 to 2018
$223k
Howard Hughes Medical InstituteNIH HHS S10 OD018027NIMH NIH HHS K99 MH113764NIMH NIH HHS R00 MH113764NIMH NIH HHS R01 MH063105NINDS NIH HHS R35 NS097333
6 · The paper itself

Abstract

Characterizing interactions of Synaptotagmin-1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X-ray crystallography revealed how the Synaptotagmin-1 C

Indexed as

Nerve Tissue ProteinsSNARE ProteinsAdaptor Proteins, Vesicular TransportCytoplasmSynaptic TransmissionAdaptor Proteins, Vesicular TransportNerve Tissue ProteinsSNARE ProteinsCa2+ sensingcomplexinneurotransmitter releaseSNAREssynaptotagminweak protein interactions

Identifiers

PMID36305864
PMCPMC9811660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.