Evidence map›Paper›PMID 36305604›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

3D-Bioprinted Phantom with Human Skin Phototypes for Biomedical Optics.

Wonjun Yim, Jiajing Zhou, Lekshmi Sasi, Jiayu Zhao, Justin Yeung, Yong Cheng, Zhicheng Jin, Wade Johnson, Ming Xu, Jorge Palma-Chavez and 6 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Wonjun YimMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.
Jiajing ZhouDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Lekshmi SasiDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Jiayu ZhaoDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Justin YeungDepartment of Bioengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Yong ChengDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Zhicheng JinDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Wade JohnsonDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Ming XuDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Jorge Palma-ChavezDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Lei FuDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Baiyan QiMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.
Maurice RetoutDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Nisarg J ShahDepartment of Nanoengineering, University of California San Diego, La Jolla, CA, 92093, USA.
Jinhye BaeMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.
Jesse V JokerstMaterials Science and Engineering Program, University of California San Diego, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0003-2829-6408

Funding

Rheumatic Diseases Research Training GrantT32AR064194 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GARY S FIRESTEIN, Monica Guma · 2013 to 2026
$3.8M
Vevo LAZR Photoacoustic Imaging SystemS10OD021821 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HALL, DAVID J · 2016 to 2016
$594k
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
Non-Invasive Detection and Staging of Decubitus and Diabetic UlcersR21AG065776 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JOKERST, JESSE VINCENT · 2020 to 2021
$575k
Microparticles Modulating Regulatory T cells in Periodontal DiseaseR03DE031009 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHAH, NISARG J. · 2021 to 2022
$286k
NIAMS NIH HHS T32 AR064194NIA NIH HHS R21 AG065776NIDCR NIH HHS R03 DE031009NIH HHS R21AG065776NIH HHS S10 OD021821NIH HHS S10OD021821NIH HHS S10 OD023527NIH HHS S10OD023527NIH HHS T32AR064194
6 · The paper itself

Abstract

3D-bioprinted skin-mimicking phantoms with skin colors ranging across the Fitzpatrick scale are reported. These tools can help understand the impact of skin phototypes on biomedical optics. Synthetic melanin nanoparticles of different sizes (70-500 nm) and clusters are fabricated to mimic the optical behavior of melanosome. The absorption coefficient and reduced scattering coefficient of the phantoms are comparable to real human skin. Further the melanin content and distribution in the phantoms versus real human skins are validated via photoacoustic (PA) imaging. The PA signal of the phantom can be improved by: 1) increasing melanin size (3-450-fold), 2) increasing clustering (2-10.5-fold), and 3) increasing concentration (1.3-8-fold). Then, multiple biomedical optics tools (e.g., PA, fluorescence imaging, and photothermal therapy) are used to understand the impact of skin tone on these modalities. These well-defined 3D-bioprinted phantoms may have value in translating biomedical optics and reducing racial bias.

Indexed as

MelaninsSkinHumansOptical ImagingOptics and PhotonicsPhantoms, ImagingMelanins3D bioprintingartificial skinsbioinspired materialsbiophotonic devices

Identifiers

PMID36305604
PMCPMC9868107

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.