Evidence map›Paper›PMID 36305577›Full record

Trial reportJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2023

Clinical and neurophysiological characteristics of 89 patients with narcolepsy and cataplexy from the Russian Narcolepsy Network.

Alexander Kuts, Michael Poluektov, Alexander Zakharov, Vlada Govzman, Irina Ponomareva, Eduard Yakupov, Irina Zavalko, Olga Tikhomirova, Yurii Sviryaev, Alexey Yakovlev and 3 more

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05375890 (Clinical and Neurophysiological Characteristics of Narcolepsy in Russia Basing on Clinical, Polysomnographic and Genome-wide Association Analyses of Narcolepsy With Cataplexy), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05375890 completednot on this map

Clinical and Neurophysiological Characteristics of Narcolepsy in Russia Basing on Clinical, Polysomnographic and Genome-wide Association Analyses of Narcolepsy With Cataplexy: a European Narcolepsy Network Study of 2013

Typeobservational_patient_registrySponsorI.M. Sechenov First Moscow State Medical UniversityRan2019 to 2023Enrolled89ConditionsNarcolepsy Type 1Armsno intervention
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The Lehigh Valley Health Network Narcolepsy Cohort: clinical and polysomnographic analysis of 304 cases.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 2 countries.

Alexander KutsSechenov University, Moscow, Russia.
Michael PoluektovSechenov University, Moscow, Russia.
Alexander ZakharovDepartment of Neurology and Neurosurgery, Samara State Medical University, Samara, Russia.
Vlada GovzmanClinical Hospital "RZD-Medicine", Khabarovsk, Russia.
Irina PonomarevaRegional Clinical Hospital No. 3, Chelyabinsk, Russia.
Eduard YakupovKazan State Medical University, Kazan, Russia.
Irina ZavalkoResearch Center of Neurology, Moscow, Russia.
Olga TikhomirovaNikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, Saint-Petersburg, Russia.
Yurii SviryaevAlmazov National Medical Research Centre, Saint-Petersburg, Russia.
Alexey YakovlevNovosibirsk State Medical University, Novosibirsk, Russia.
Alexander PolyakovV.M. Bekhterev National Research Medical Center for Psychiatry and Neurology, Saint-Petersburg, Russia.
Alexander MelnikovFSBI NMRCO FMBA Russia, Moscow, Russia.
Claudio L A BassettiSechenov University, Moscow, Russia.
Sechenov University · RUFederal Almazov North-West Medical Research Centre · RUKazan State Medical University · RUNikiforov Russian Center of Emergency and Radiation Medicine · RUNovosibirsk State Medical University · RURegional Clinical Hospital No 4 · RUResearch Center of Neurology · RUSamara State Medical University · RUSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesThe first reports of narcolepsy with cataplexy in Russia were made by Mankovsky (The pathogenesis of narcolepsy (the case of epidemic encephalitis with cataplexy) published in the Sovremennaya psihonevrologia) in 1925. The largest series of patients (n = 110) was reported by A. Vein (doctoral thesis: Hypersomnia Syndrome) in 1964. However, until today, narcolepsy remained relatively unknown in Russia. The aim of this study is to report clinical and polysomnography (PSG)/multiple sleep latency test (MSLT) results in the Russian population and compare them with the European Narcolepsy Network (EU-NN) data (n = 1099) reported.

methodsEleven sleep centers from Russia agreed to participate and completed a questionnaire including 58 questions concerning demographic, clinical, PSG, and MSLT data.

resultsThere were 89 patients with a mean age of 35.6 ± 16.9 years (± here and further indicates standard deviation), 58% males, and 42% females. Narcolepsy started at a mean age of 25.6 ± 14.6 years (range 5-74 years). The mean Epworth Sleepiness Scale score was 18.4 ± 3.5 points (range: 11-24). Sleep paralysis was reported by 59.1%, and hallucinations by 82% of patients. In MSLT, ≥ 2 sleep-onset REM (rapid eye movement) periods (SOREMPs) were found in 81.6%. No center provided human leukocyte antigen (HLA) or cerebral spinal fluid hypocretin data.

conclusionsClinical and neurophysiological data from this first study of the Russian Narcolepsy Network suggest a similar profile to the recently reported EU-NN data. The more severe and higher percentage of patients with cataplexy and presenting with both excessive daytime sleepiness and cataplexy may reflect low awareness of narcolepsy in Russia. CLINICAL

trial registrationRegistry: ClinicalTrials.gov; URL: https://clinicaltrials.gov/ct2/show/NCT05375890; Name: Clinical and Neurophysiological Characteristics of Narcolepsy; Identifier: NCT05375890. CITATION: Kuts A, Poluektov M, Zakharov A, et al. Clinical and neurophysiological characteristics of 89 patients with narcolepsy and cataplexy from the Russian Narcolepsy Network.

Indexed as

CataplexyDisorders of Excessive SomnolenceNarcolepsyAdolescentAdultAgedChildChild, PreschoolFemaleHumansMaleMiddle AgedSleepSleep, REMYoung Adultcataplexyexcessive daytime sleepinessMSLTnarcolepsyPSGRussia

Identifiers

PMID36305577
PMCPMC9892735
OpenAlexW4307502721

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.