Evidence map›Paper›PMID 36305372›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2023

Iron-Catalysed Carbene Transfer to Isocyanides as a Platform for Heterocycle Synthesis.

Thomas R Roose, H Daniel Preschel, Helena Mayo Tejedor, Jasper C Roozee, Trevor A Hamlin, Bert U W Maes, Eelco Ruijter, Romano V A Orru

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Thomas R RooseDepartment of Chemistry & Pharmaceutical Sciences Amsterdam Institute for Molecular & Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4567-1302
H Daniel PreschelDepartment of Chemistry & Pharmaceutical Sciences Amsterdam Institute for Molecular & Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Helena Mayo TejedorDepartment of Chemistry & Pharmaceutical Sciences Amsterdam Institute for Molecular & Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Jasper C RoozeeDepartment of Chemistry & Pharmaceutical Sciences Amsterdam Institute for Molecular & Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.
Trevor A HamlinDepartment of Chemistry & Pharmaceutical Sciences Amsterdam Institute for Molecular & Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-5128-1004
Bert U W MaesOrganic Synthesis Division Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, B-2020, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-0431-7606
Eelco RuijterDepartment of Chemistry & Pharmaceutical Sciences Amsterdam Institute for Molecular & Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1105-3947
Romano V A OrruDepartment of Chemistry & Pharmaceutical Sciences Amsterdam Institute for Molecular & Life Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0003-1142-6798
Vrije Universiteit Amsterdam · NLMaastricht University · NLUniversity of Antwerp · BE

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek 713.017.002
6 · The paper itself

Abstract

An iron-catalysed carbene transfer reaction of diazo compounds to isocyanides has been developed. The resulting ketenimines are trapped in situ with various bisnucleophiles to access a range of densely functionalized heterocycles (pyrimidinones, dihydropyrazolones, 1H-tetrazoles) in a one-pot process. The electron-rich Hieber anion ([Fe(CO)

Indexed as

carbene transferHieber anioniron catalysisisocyanideketenimine

Identifiers

PMID36305372
PMCPMC10108253
OpenAlexW4307460041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.