Evidence map›Paper›PMID 36305288›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors.

Morteza Abdoli, Alessandro Bonardi, Claudiu T Supuran, Raivis Žalubovskis

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Investigation onPharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Morteza AbdoliFaculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia.ORCID 0000-0003-1647-4262
Alessandro BonardiNeurofarba Department, Università degli Studi di Firenze, Florence, Italy.
Claudiu T SupuranNeurofarba Department, Università degli Studi di Firenze, Florence, Italy.ORCID 0000-0003-4262-0323
Raivis ŽalubovskisFaculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia.ORCID 0000-0002-9471-1342

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A one-pot two-step protocol was developed for the synthesis of a series of novel 4-cyanamidobenzenesulfonamides from easily accessible methyl (4-sulfamoylphenyl)-carbamimidothioate. The new sulphonamides were investigated as inhibitors of the enzyme carbonic anhydrase (CA, EC 4.2.1.1), the human (h) cytosolic isoforms hCA I, II, VII, and XIII, as well as three bacterial enzymes belonging to the β-CA class, MscCA from

Indexed as

Carbonic Anhydrase InhibitorsSulfonamidesCarbonic AnhydrasesHumansMolecular StructureProtein IsoformsStructure-Activity RelationshipCarbonic Anhydrase InhibitorsCarbonic AnhydrasesProtein IsoformsSulfonamidesCarbonic anhydrasecyanamidesMammaliicoccus (Staphylococcus) sciuriSalmonella enterica (serovar Typhimurium)sulphonamides

Identifiers

PMID36305288
PMCPMC9621233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.