Evidence map›Paper›PMID 36305047›Full record

ArticleJournal of cellular and molecular medicine2022

Identification of potential lncRNA-miRNA-mRNA regulatory network contributing to aldosterone-producing adenoma.

Minghui Bao, Haotong Li, Jianping Li

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Minghui BaoDepartment of Cardiology, Peking University First Hospital, Peking University, Beijing, China.ORCID 0000-0001-8196-2559
Haotong LiNational Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID 0000-0001-7404-9526
Jianping LiDepartment of Cardiology, Peking University First Hospital, Peking University, Beijing, China.
Peking University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

The National Natural Science Foundation of China 82000432The Peking University First Hospital Seed Foundation 2020SF01
6 · The paper itself

Abstract

Aldosterone-producing adenoma (APA) is a common cause of secondary hypertension. This study aimed to explore the lncRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) network to uncover molecular mechanism underlying APA. The mRNA and lncRNA expression data of APA and adjacent adrenal gland (AAG) from GSE60044, GSE64957 and GSE101894 were obtained from the Gene Expression Omnibus (GEO) database to analyse differentially expressed genes (DEGs) and lncRNAs (DElncs). Hub genes were identified by robust rank aggregation (RRA) and protein-protein interaction (PPI) network analysis. The miRcode and miRWalk network tools were used to construct the ceRNA network. 1526 upregulated and 1512 downregulated DEGs were identified, which are mainly enriched in extracellular matrix and Ca

Indexed as

AdenomaMicroRNAsRNA, Long NoncodingAldosteroneGene Regulatory NetworksHumansReceptors, G-Protein-CoupledRNA, MessengerAldosteroneGPRC5B protein, humanMicroRNAsReceptors, G-Protein-CoupledRNA, Long NoncodingRNA, Messengeraldosterone-producing adenomacompeting endogenous RNAhub genehypertensionlncRNAtranscriptional analysis

Identifiers

PMID36305047
PMCPMC9667512
OpenAlexW4307502924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.