ArticleAlzheimer's & dementia (New York, N. Y.)2022
Free water derived by multi-shell diffusion MRI reflects tau/neuroinflammatory pathology in Alzheimer's disease.
Article in Alzheimer's & dementia (New York, N. Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 38 citations in OpenAlex.
- The role of glymphatic dysfunction in cerebral small vessel disease and vascular cognitive impairment, and therapeutic implications.International journal of stroke : official journal of the International Stroke Society · 2026Review
- Advanced diffusion MRI tract signatures in Alzheimer's disease, dementia with Lewy bodies, and the FTD/PPA spectrum.NeuroImage · 2026Review
- White matter microstructure of sensorimotor projection fibers in chronic low back pain.Pain reports · 2026Article
- 3D quantitative synthetic MRI for assessing Alzheimer's clinical syndrome, subjective cognitive impairment, and mild cognitive impairment.Neuroradiology · 2026Article
- Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis.BMC medicine · 2026Article
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Association of glymphatic dysfunction, free water, white matter integrity and long-term memory performance in aging autistic adults.Molecular autism · 2026Article
- Reproducibility and Reliability of Free-Water-Corrected Diffusion Tensor Imaging of the Brain: Revisited.Human brain mapping · 2026Article
- 40 Years of diffusion MRI in the brain: From history to emerging frontiers.Imaging neuroscience (Cambridge, Mass.) · 2026Review
- Synaptic micromechanics and brain softening as a mechanobiological hypothesis for Alzheimer's disease.Frontiers in neuroscience · 2026Article
- Neuroradiological features across major psychiatric disorders and behavioral variant of Alzheimer's disease: a concise multimodal synthesis.Psychoradiology · 2026Review
- Article
- Diffusion Basis Restricted Fraction as a Putative Magnetic Resonance Imaging Marker of Neuroinflammation: Histological Evidence, Diagnostic Accuracy, and Translational Potential.Life (Basel, Switzerland) · 2025Review
- Imaging markers of neuroinflammation in aging and Alzheimer's disease and related dementia: A comprehensive review.Neuroscience and biobehavioral reviews · 2025Review
- Mapping Alzheimer's disease pathology using free water through integrated analysis of plasma biomarkers, microstructural DTI metrics, and macrostructural MRI measures.Scientific reports · 2025Article
- Layer-Dependent Effect of Aβ-Pathology on Cortical Microstructure With Ex Vivo Human Brain Diffusion MRI at 7 Tesla.Human brain mapping · 2025Article
- Article
- Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Transcallosal white matter and cortical gray matter variations in autistic adults aged 30-73 years.Molecular autism · 2025Article
- Perivascular and parenchymal brain fluid diffusivity in patients with a recent small subcortical infarct.Neuroradiology · 2025Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Free-water (FW) imaging, a new analysis method for diffusion magnetic resonance imaging (MRI), can indicate neuroinflammation and degeneration. We evaluated FW in Alzheimer's disease (AD) using tau/inflammatory and amyloid positron emission tomography (PET). Methods: Seventy-one participants underwent multi-shell diffusion MRI, Results: In AD-S group, there was a significant positive correlation between FW and Discussion: FW imaging could be a biomarker for tau in AD alongside clinical correlations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.