ArticleFrontiers in psychiatry2022
Behavioral pathway to a broken heart: The link between adverse childhood experiences, depression, physical exercise and cardiovascular health.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The influence of physical exercise on negative emotions in adolescents: a meta-analysis.Frontiers in psychiatry · 2024Pooled it
- Exercise intervention and improvement of negative emotions in children: a meta-analysis.BMC pediatrics · 2023Pooled it
- Sex-specific associations of physical frailty with cardiac structure and function: a cross-sectional study based on UK Biobank.BMC cardiovascular disorders · 2026Article
- The longitudinal impact of adverse childhood experiences on college students' intrinsic motivation for physical exercise: the chain mediating effect of meaning in life and psychological resilience.Frontiers in psychology · 2026Article
- [Traumatic childhood experiences and cardiovascular health using the example of adults with congenital heart disease].Der Nervenarzt · 2026Article
- Association of childhood adversity and depression with cardiovascular health in youth with perinatal HIV 1 in Uganda.Discover public health · 2026Article
- The moderating effect of lifetime physical activity on brain alterations related to adverse childhood experiences.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Parental imprisonment, childhood behavioral problems, and adolescent and young adult cardiometabolic risk: results from a prospective Australian birth cohort study.Health & justice · 2025Article
- Increased epicardial tissue and reduced TAPSE and MAPSE scores in borderline personality disorders. Early indicators for cardiovascular risk?Frontiers in psychiatry · 2025Article
- Short sleep duration in adults with congenital heart disease is associated with epicardial adipose tissue accumulation.Frontiers in psychiatry · 2025Article
- Uncovering psychologically mediated pathways to cardiovascular diseases: depressive symptoms as a mediator between childhood maltreatment and single or multiple cardiovascular disease comorbidities.Frontiers in psychiatry · 2025Article
- Impact of childhood household support on depression and self-reported mental and physical health.PloS one · 2025Article
- A role for adverse childhood experiences and depression in preeclampsia.Journal of clinical and translational science · 2024Article
- The role of epicardial adipose tissue dysfunction in cardiovascular diseases: an overview of pathophysiology, evaluation, and management.Frontiers in endocrinology · 2023Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aim: Adverse childhood experiences (ACEs) are a major risk factor for unfavorable behavioral, mental and health outcomes later in life. However, the precise pathway Methods: 210 adult congenital heart disease outpatients (mean age 35.5 y, 43% female) completed a thorough cardiac and psychiatric evaluation. Psychiatric measurements included an expert interview, the childhood trauma questionnaire (CTQ), Beck's depression inventory II (BDI-II), quality of life and the global scale of functioning, amongst others. All patients completed a full cardiac workup including EAT assessment using echocardiography. We then computed bootstrapping mediation models using ACEs as a predictor, depression and physical activity as mediators and EAT as dependent variable in PROCESS. Results: CTQ scores had a significant indirect effect on EAT Conclusion: Using mediation analyses, we show that adverse childhood events are linked to increased depressive symptoms, which are linked to decreased physical activity, which in turn are linked to a higher amount of epicardial adipose tissue. While other pathways most certainly exist and replication is needed, this suggests a meaningful pathway
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