Evidence map›Paper›PMID 36304298›Full record

ArticleFrontiers in bioinformatics2022

Pathway Tools Management of Pathway/Genome Data for Microbial Communities.

Peter D Karp, Suzanne Paley, Markus Krummenacker, Anamika Kothari, Michael J Wannemuehler, Gregory J Phillips

Abstract read
In one paragraph

Article in Frontiers in bioinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Genome mining of metabolic gene clusters in the Rubiaceae family.Computational and structural biotechnology journal · 2024
    Article
  5. Isolation and characterization of aApplied and environmental microbiology · 2024
    Article
  6. Comparative genomics of a novelMicrobial genomics · 2024
    Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Peter D KarpBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Suzanne PaleyBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Markus KrummenackerBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Anamika KothariBioinformatics Research Group, Artificial Intelligence Center, SRI International, Menlo Park, CA, United States.
Michael J WannemuehlerDepartment of Veterinary Microbiology, Iowa State University, Ames, IA, United States.
Gregory J PhillipsDepartment of Veterinary Microbiology, Iowa State University, Ames, IA, United States.

Funding

The MetaCyc & BioCyc Pathway/Genome Databases (SRI Proposal ECU 14-630)R01GM080746 · NIGMS · SRI INTERNATIONAL · PI CASPI, RON, KARP, PETER D · 2007 to 2021
$15.6M
Development and Support of the Pathway Tools SoftwareR01AI160719 · NIAID · SRI INTERNATIONAL · PI PETER D KARP · 2021 to 2026
$5.9M
NIAID NIH HHS R01 AI160719NIGMS NIH HHS R01 GM080746
6 · The paper itself

Abstract

The Pathway Tools (PTools) software provides a suite of capabilities for storing and analyzing integrated collections of genomic and metabolic information in the form of organism-specific Pathway/Genome Databases (PGDBs). A microbial community is represented in PTools by generating a PGDB from each metagenome-assembled genome (MAG). PTools computes a metabolic reconstruction for each organism, and predicts its operons. The properties of individual MAGs can be investigated using the many search and visualization operations within PTools. PTools also enables the user to investigate the properties of the microbial community by issuing searches across the full community, and by performing comparative operations across genome and pathway information. The software can generate a metabolic network diagram for the community, and it can overlay community omics datasets on that network diagram. PTools also provides a tool for searching for metabolic transformation routes across an organism community.

Indexed as

data managementgenome databasemetabolic pathwaysmetabolic routesmicrobiome

Identifiers

PMID36304298
PMCPMC9580912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.