Evidence map›Paper›PMID 36304270›Full record

ArticleFrontiers in bioinformatics2022

Mimetic Neural Networks: A Unified Framework for Protein Design and Folding.

Moshe Eliasof, Tue Boesen, Eldad Haber, Chen Keasar, Eran Treister

Abstract read
In one paragraph

Article in Frontiers in bioinformatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Graph representation learning for structural proteomics.Emerging topics in life sciences · 2021
    Review
  3. Protein Design with Deep Learning.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Moshe EliasofDepartment of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Tue BoesenDepartment of EOAS, The University of British Columbia, Vancouver, BC, Canada.
Eldad HaberDepartment of EOAS, The University of British Columbia, Vancouver, BC, Canada.
Chen KeasarDepartment of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Eran TreisterDepartment of Computer Science, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advancements in machine learning techniques for protein structure prediction motivate better results in its inverse problem-protein design. In this work we introduce a new graph mimetic neural network, MimNet, and show that it is possible to build a reversible architecture that solves the structure and design problems in tandem, allowing to improve protein backbone design when the structure is better estimated. We use the ProteinNet data set and show that the state of the art results in protein design can be met and even improved, given recent architectures for protein folding.

Indexed as

deep learninggraph neural networksprotein designprotein foldingprotein sructure prediction

Identifiers

PMID36304270
PMCPMC9580911

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.