ArticleFrontiers in public health2022
Characteristics of Graves' disease in children and adolescents in Nanjing: A retrospective investigation study.
Article in Frontiers in public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 12 citations in OpenAlex.
- Clinical utility of TRAb reduction in predicting remission in pediatric Graves' disease.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026Article
- Maternal vitiligo is associated with increased autoimmune and atopic disease in offspring: A nationwide birth cohort study.JAAD international · 2026Article
- Clinical Pattern of Graves' Disease and Management Preferences Among Pediatric Endocrinologists in Saudi Arabia, A Decade of Experience.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- A case report of Graves' disease combined with pseudohypoaldosteronism type IID in a child.Translational pediatrics · 2025Article
- Repurposing FDA approved drugs for psoriasis indications through integrated molecular docking, one-SVM algorithm, and molecular dynamics simulation approaches.Scientific reports · 2025Article
- Graves' disease in Children: A Case Report of Rare Occurrence.Pakistan journal of medical sciences · 2025Article
- Hyperthyroidism Presenting as Jaundice in a Child.Oman medical journal · 2024Article
- Article
- Effect of methimazole treatment on Th1, Th17, and Th22 lymphocytes in pediatric Graves' disease patients.Frontiers in immunology · 2024Article
- Clinically practical pharmacometrics computer model to evaluate and personalize pharmacotherapy in pediatric rare diseases: application to Graves' disease.Frontiers in medicine · 2023Article
- Functional enrichment analysis of mutated genes in children with hyperthyroidism.Frontiers in endocrinology · 2023Article
- Clinical Characteristics and Surgical Outcomes of Paediatric Thyroid Disorders in a Nigerian Mission Hospital: A Nine-Year Review.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: This cross-sectional study analyzed the clinical characteristics of newly diagnosed Graves' disease (GD) in children and adolescents to provide clinical evidence for the early diagnosis of GD. Method: From 2013 to 2019, information on children and adolescents with newly diagnosed GD admitted to the Department of Endocrinology, Children's Hospital of Nanjing Medical University, was collected, including clinical features and laboratory tests. The data were summarized and statistically analyzed. Result: This study included 204 cases of newly diagnosed GD, with 158 females and 46 males. The average age at initial diagnosis was 8.9 ± 2.9 years. A total of 132 cases (64.7%) had symptoms before puberty, and 72 cases (35.3%) had symptoms during puberty. Goiter was detected in 193 cases (94.6%). There were 140 cases (68.6%) of exophthalmos, and 21.4% (30/140) were infiltrative. At initial diagnosis, 10 cases (4.9%) reported leukopenia, 18 cases (8.8%) reported neutropenia, and 15 cases (7.4%) reported mild anemia. There was 1 (0.5%) case of thrombocytopenia and 1 (0.5%) case of agranulocytosis. Fifty-four cases (26.5%) had impaired liver function. Conclusion: GD is more common in female children and adolescents. Parents may ignore their children's hypermetabolic symptoms in the early stages of GD. Routine blood and liver function tests are recommended at initial diagnosis to exclude abnormal hemogram and liver function.
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