ArticleFrontiers in pharmacology2022
Risk of major adverse events associated with gabapentinoid and opioid combination therapy: A systematic review and meta-analysis.
Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04705480 (Pregabalin vs. Gabapentin on Reducing Opioid Usage in Trauma Patients), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pregabalin vs. Gabapentin on Reducing Opioid Usage in Trauma Patients
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- The role of combined adjuvant therapeutic drugs in modulating opioid dosage and pain status in cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Pooled it
- Healthcare Practitioner and Other Professionals' Perspectives on Gabapentinoid Misuse and Dependence: A Systematic Review of Qualitative Studies.European journal of pain (London, England) · 2025Pooled it
- Research trends and hotspots of neuropathic pain in neurodegenerative diseases: a bibliometric analysis.Frontiers in immunology · 2023Pooled it
- The Combination of Buprenorphine and Pregabalin in the Management of Peripheral Neuropathic Pain: A Phase IV, Randomized, Double-Blind and Placebo-Controlled Clinical Trial.European journal of pain (London, England) · 2026Trial
- Adjunctive tonic motor activation enables opioid reduction for refractory restless legs syndrome: a prospective, open-label, single-arm clinical trial.BMC neurology · 2023Trial
- Molecular Mechanisms of Acute Drug Toxicity in Polypharmacy: Analgesic-Psychotropic Interactions.International journal of molecular sciences · 2026Review
- Prevalence and Patterns of Non-Medical Gabapentinoid Use in a General Population Sample: Findings From the Australian National Drug Strategy Household Survey.Drug and alcohol review · 2026Article
- Comparative safety and health service utilization for gabapentin versus non-steroidal anti-inflammatory drugs for cervical radiculopathy: A retrospective cohort study of academic centers.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2026Article
- Personalized Multimodal and Opioid-Sparing Analgesia for Postoperative Pain Management: Enhancing Recovery and Addressing the Post-Discharge Gap.Journal of pain research · 2026Review
- Longitudinal Pain Medication Use Among US Older Adults After a Hip Fracture.Journal of the American Medical Directors Association · 2025Article
- Suzetrigine - A Novel FDA-Approved Analgesic - Opportunities, Challenges and Future Perspectives: A Perspective Review.Health science reports · 2025Article
- Adverse respiratory events during treatment with gabapentin and opioids among older adults with spine-related conditions: a propensity-matched cohort study in the US Medicare population.The spine journal : official journal of the North American Spine Society · 2025Article
- A Review on the Management of Symptoms in Patients with Incurable Cancer.Current oncology (Toronto, Ont.) · 2025Review
- Incidence of somnolence and dizziness induced by mirogabalin and pregabalin under opioid treatment: a single-center observational study.Journal of pharmaceutical health care and sciences · 2025Article
- Rapid Eye Movement (REM)-Predominant Central Sleep Apnea With Alpha-Delta Sleep Pattern: A Case Report.Cureus · 2025Article
- Application of a Nociceptive Test Battery to Assess Potential Synergy between Two Analgesics in Healthy Subjects.ACS pharmacology & translational science · 2025Article
- What Links Sleep and Neuropathic Pain?: A Literature Review on the Neural Circuits for Sleep and Pain Control.Nature and science of sleep · 2025Review
- Efficacy and safety of pregabalin in the management of low back pain: a comprehensive meta-analysis.Frontiers in pharmacology · 2025Review
- Incident gabapentin prescribing associated with opioid and benzodiazepine/Z-drug prescribing - a population-based longitudinal study in primary care.Frontiers in pharmacology · 2025Article
- Multimodal analgesia for postoperative pain: pursuing liberation from pain, not redemption.Annals of coloproctology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.