Evidence map›Paper›PMID 36304137›Full record

ArticleInternational journal of pharmaceutics: X2022

Quantitative comparison of the protein corona of nanoparticles with different matrices.

Ilaria Ottonelli, Jason Thomas Duskey, Filippo Genovese, Francesca Pederzoli, Riccardo Caraffi, Marta Valenza, Giovanni Tosi, Maria Angela Vandelli, Barbara Ruozi

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ilaria OttonelliNanotech Lab, Te.Far.T.I., Department of Life Sciences, Via Campi 103, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Jason Thomas DuskeyNanotech Lab, Te.Far.T.I., Department of Life Sciences, Via Campi 103, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Filippo GenoveseCIGS, Centro Interdipartimentale Grandi Strumenti, Via Campi 213A, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Francesca PederzoliNanotech Lab, Te.Far.T.I., Department of Life Sciences, Via Campi 103, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Riccardo CaraffiNanotech Lab, Te.Far.T.I., Department of Life Sciences, Via Campi 103, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Marta ValenzaDepartment of Biosciences, Via Giovanni Celoria 26, University of Milan, 20133 Milan, Italy.
Giovanni TosiNanotech Lab, Te.Far.T.I., Department of Life Sciences, Via Campi 103, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Maria Angela VandelliNanotech Lab, Te.Far.T.I., Department of Life Sciences, Via Campi 103, University of Modena and Reggio Emilia, 41125 Modena, Italy.
Barbara RuoziNanotech Lab, Te.Far.T.I., Department of Life Sciences, Via Campi 103, University of Modena and Reggio Emilia, 41125 Modena, Italy.
University of Modena and Reggio Emilia · ITUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanoparticles (NPs) are paving the way for improved treatments for difficult to treat diseases diseases; however, much is unknown about their fate in the body. One important factor is the interaction between NPs and blood proteins leading to the formation known as the "protein corona" (PC). The PC, consisting of the Hard (HC) and Soft Corona (SC), varies greatly based on the NP composition, size, and surface properties. This highlights the need for specific studies to differentiate the PC formation for each individual NP system. This work focused on comparing the HC and SC of three NPs with different matrix compositions: a) polymeric NPs based on poly(lactic-

Indexed as

CholesterolLipidic nanoparticlesNanomedicinePolymeric PLGA nanoparticlesProtein coronaTargeted nanomedicines

Identifiers

PMID36304137
PMCPMC9594119
OpenAlexW4306971034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.