Evidence map›Paper›PMID 36304122›Full record

ArticleiScience2022

Kinesin-2 motors differentially impact biogenesis of extracellular vesicle subpopulations shed from sensory cilia.

Michael Clupper, Rachael Gill, Malek Elsayyid, Denis Touroutine, Jeffrey L Caplan, Jessica E Tanis

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Superoxide dismutase impacts extracellular vesicle biogenesis and uptake.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Review
  7. bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Journal of biosciences · 2025
    Review
  12. Extracellular vesicles.Genetics · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Michael ClupperDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Rachael GillDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Malek ElsayyidDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Denis TouroutineDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Jeffrey L CaplanDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Jessica E TanisDepartment of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
University of Delaware · US

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
Polycystins, cilia, and extracellular vesicles in C. elegansR01DK059418 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Maureen M Barr · 2001 to 2026
$9.9M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Chemistry-Biology Interface Predoctoral Training Grant 2024-2029T32GM133395 · NIGMS · UNIVERSITY OF DELAWARE · PI Catherine Leimkuhler Grimes · 2019 to 2026
$3.7M
Supplement to Elucidating biogenesis and cargo sorting mechanisms for discrete extracellular vesicle subpopulations in C. elegansR01GM135433 · NIGMS · UNIVERSITY OF DELAWARE · PI TANIS, JESSICA E · 2020 to 2024
$1.8M
Spinning Disk Confocal and Single Molecule Localization MicroscopeS10OD030321 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2021 to 2021
$562k
Zeiss LSM710 Inverted Confocal MicroscopeS10OD016361 · OD · UNIVERSITY OF DELAWARE · PI CAPLAN, JEFFREY L · 2015 to 2015
$444k
NIDDK NIH HHS R01 DK059418NIGMS NIH HHS P20 GM103446NIGMS NIH HHS R01 GM135433NIGMS NIH HHS T32 GM133395NIH HHS P40 OD010440NIH HHS S10 OD016361NIH HHS S10 OD030321
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are bioactive lipid-bilayer enclosed particles released from nearly all cells. One specialized site for EV shedding is the primary cilium. Here, we discover the conserved ion channel CLHM-1 as a ciliary EV cargo. Imaging of EVs released from sensory neuron cilia of

Indexed as

Molecular neuroscienceNatural sciencesNeuroscience

Identifiers

PMID36304122
PMCPMC9593189
OpenAlexW4301398402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.